Effects of Capsaicin on Lipid Catabolism in 3T3-L1 Adipocytes

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a pungent ingredient of red peppers, and has been reported to reduce body weight gain and adiposity in rodents. The present study investigated the effects of capsaicin on lipid catabolism in differentiated 3T3-L1 adipocytes. Capsaicin decreased the int...

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Bibliographic Details
Published in:Phytotherapy research 2011-06, Vol.25 (6), p.935-939
Main Authors: Lee, Mak-Soon, Kim, Chong-Tai, Kim, In-Hwan, Kim, Yangha
Format: Article
Language:English
Subjects:
3T3-L1 adipocytes
3T3-L1 Cells
adipocytes
Adipocytes - drug effects
Adipocytes - metabolism
adiposity
Animals
Biological and medical sciences
capsaicin
Capsaicin - pharmacology
Capsicum - chemistry
carnitine
gene expression regulation
General pharmacology
genes
glycerol
glycerol release
hydrolysis
ingredients
lipid catabolism
lipid content
Lipids - analysis
Lipolysis - drug effects
Medical sciences
messenger RNA
metabolism
Mice
mRNA
peppers
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
RNA, Messenger - genetics
rodents
Sterol Esterase - metabolism
triacylglycerol lipase
Triglycerides - metabolism
weight gain
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Summary:Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a pungent ingredient of red peppers, and has been reported to reduce body weight gain and adiposity in rodents. The present study investigated the effects of capsaicin on lipid catabolism in differentiated 3T3-L1 adipocytes. Capsaicin decreased the intracellular lipid content in a concentration-dependent manner. The release of glycerol into the medium was increased by the addition of capsaicin. The mRNA levels of genes involved in lipid catabolism such as hormone sensitive lipase (HSL), carnitine palmitoyl transferase-Iα (CPTI-α) and uncoupling protein 2 (UCP2) were up-regulated significantly. These results suggest that capsaicin exerts its lipolytic action by increasing the hydrolysis of triacylglycerol in adipocytes, and that these effects are mediated at least partially by regulation of the expression of multiple genes that are involved in the lipid catabolic pathway, such as HSL and CPT-Iα, and those involved in thermogenesis such as UCP2. Copyright © 2010 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.3339