Association between obesity and atopic dermatitis in childhood: A case-control study

Background Obesity in children is associated with increased asthma and atopy. Objective We sought to determine whether obesity in childhood or adolescence increases the risk of atopic dermatitis. Methods This retrospective, practice-based, case-control study randomly sampled 414 children and adolesc...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2011-05, Vol.127 (5), p.1180-1186.e1
Main Authors: Silverberg, Jonathan I., MD, PhD, MPH, Kleiman, Edward, MD, Lev-Tov, Hadar, MD, Silverberg, Nanette B., MD, Durkin, Helen G., PhD, Joks, Rauno, MD, Smith-Norowitz, Tamar A., PhD
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Adult
Age
Allergic diseases
Allergies
Allergy and Immunology
Asthma
Atopic dermatitis
atopy
Biological and medical sciences
Body Mass Index
Case-Control Studies
Child
Child, Preschool
Children
Children & youth
Dermatitis
Dermatitis, Atopic - complications
Dermatitis, Atopic - prevention & control
Dermatitis, Atopic - therapy
eczema
electronic medical records
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immune system
Immunopathology
Infant
Logistic Models
Male
Medical sciences
Metabolic diseases
Obesity
Obesity - complications
Obesity - prevention & control
Obesity - therapy
Odds Ratio
overweight
Overweight - complications
Pediatrics
Preventive health
Quality of life
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin allergic diseases. Stinging insect allergies
weight
Weight control
Weight Loss
Young Adult
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Summary:Background Obesity in children is associated with increased asthma and atopy. Objective We sought to determine whether obesity in childhood or adolescence increases the risk of atopic dermatitis. Methods This retrospective, practice-based, case-control study randomly sampled 414 children and adolescents (age, 1-21 years) with atopic dermatitis between January 2000 and December 2007 and 828 randomly sampled healthy control subjects. Information was obtained from an electronic medical record. Observations were made before the a priori hypothesis. Results Obesity in children is associated with increased atopic dermatitis (conditional logistic regression: odds ratio, 2.00; 95% CI, 1.22-3.26; P  = .006). These atopic dermatitis–predisposing effects are found when obesity started by less than 2 years of age (adjusted odds ratio [aOR], 15.10; 95% CI, 1.51-151.21; P  = .02) and 2 to 5 years (aOR, 2.58; 95% CI, 1.24-5.41; P  = .01) but not greater than 5 years (aOR, 1.32; 95% CI, 0.66-2.64; P  = .43) and when obesity was prolonged for 2.5 to 5 years (aOR, 2.64; 95% CI, 1.13-6.18; P  = .03) and greater than 5 years (aOR, 3.40; 95% CI, 1.34-8.63; P  = 0.01). Obesity is associated with more severe atopic dermatitis (ordinal logistic regression: aOR, 2.37; 95% CI, 1.24-5.37; P  = .01). Obese children who eventually have atopic dermatitis require more frequent pediatrician visits for the management of atopic dermatitis (ordinal logistic regression: aOR, 2.22; 95% CI, 1.12-4.50; P  = .03). Conclusion Prolonged obesity in early childhood is a risk factor for atopic dermatitis. Weight loss might be an important approach for the prevention and treatment of atopic dermatitis in children.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2011.01.063