Antibody dynamics after tick-borne encephalitis and measles–mumps–rubella vaccination in children post early thymectomy

Abstract Thymectomized patients (TP) showed a delayed humoral immune response to tick-borne-encephalitis-virus (TBEV) vaccination, which served as a neo-antigen. From the previously published cohort, the TBEV-specific IgG concentrations and avidities were analyzed in 17 TP compared to 30 non-thymect...

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Bibliographic Details
Published in:Vaccine 2010-11, Vol.28 (51), p.8053-8060
Main Authors: Zlamy, Manuela, Würzner, Reinhard, Holzmann, Heidemarie, Brandstätter, Anita, Jeller, Verena, Zimmerhackl, Lothar Bernd, Prelog, Martina
Format: Article
Language:English
Subjects:
Adolescent
Aging
Allergy and Immunology
Antibodies
Antibodies, Viral - blood
Antibody Affinity
Applied microbiology
Arboviral encephalitis
Arboviroses
Avidity
Biological and medical sciences
Child
Child, Preschool
Children
Cytomegalovirus
Data processing
Female
Fundamental and applied biological sciences. Psychology
Heart surgery
Human viral diseases
Humans
Immune response
Immune response (humoral)
Immune system
Immunocompromised Host
Immunoglobulin G
Immunoglobulin G - blood
Immunological memory
Infant
Infectious diseases
Male
Measles
Measles-Mumps-Rubella Vaccine - administration & dosage
Measles-Mumps-Rubella Vaccine - immunology
Medical research
Medical sciences
Microbiology
Mumps
Rubella
Studies
Thymectomy
Tick-borne encephalitis
Tick-borne encephalitis vaccination
Time Factors
Tropical viral diseases
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
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Summary:Abstract Thymectomized patients (TP) showed a delayed humoral immune response to tick-borne-encephalitis-virus (TBEV) vaccination, which served as a neo-antigen. From the previously published cohort, the TBEV-specific IgG concentrations and avidities were analyzed in 17 TP compared to 30 non-thymectomized healthy controls (HC) 220 weeks after the first TBE vaccination to identify patients with waning antibodies. Only in HC, increase of avidity was significant between 8 and 220 weeks ( p < 0.001), whereas TP showed a lower avidity maturation at week 48 ( p < 0.05). Cytomegalovirus (CMV) seropositivity at vaccination did not influence the humoral immune response. The ability of TP to maintain measles, mumps and rubella (MMR)-specific antibodies at least 8 years post (MMR) vaccination was evaluated in the serum samples of TP, retrospectively. Although all TP had MMR vaccination at least 6 months after thymectomy, TP showed no significant difference regarding MMR-specific IgG concentrations or avidities compared to HC. Regarding TBE vaccination, the data confirmed the previous observation of a delayed primary immune response in TP to TBE vaccine and also revealed an altered memory priming by paucity of high-avidity antibodies.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2010.10.002