Polyomavirus BK Replication in Liver Transplant Candidates with Normal Renal Function

Abstract Polyomavirus-associated nephropathy (PVAN) has a predilection for kidney rather than for other solid organ transplants such as the liver. Immunosuppression is widely recognized to be a major risk factor for PVAN development. Since end-stage liver disease (ESLD) patients are immunocompromise...

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Bibliographic Details
Published in:Transplantation proceedings 2011-05, Vol.43 (4), p.1142-1144
Main Authors: Mitterhofer, A.P, Tinti, F, Mordenti, M, Pietropaolo, V, Colosimo, M, Ginanni Corradini, S, Chiarini, F, Rossi, M, Ferretti, G, Brunini, F, Poli, L, Berloco, P.B, Taliani, G
Format: Article
Language:English
Subjects:
Biological and medical sciences
BK Virus - genetics
BK Virus - pathogenicity
End Stage Liver Disease - immunology
End Stage Liver Disease - physiopathology
End Stage Liver Disease - surgery
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Infectious diseases
Italy
Kidney - immunology
Kidney - physiopathology
Kidney - virology
Liver Transplantation
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Polyomavirus Infections - immunology
Polyomavirus Infections - physiopathology
Polyomavirus Infections - virology
RNA, Viral - blood
RNA, Viral - urine
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Viral diseases
Viremia
Virus Replication
Waiting Lists
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Summary:Abstract Polyomavirus-associated nephropathy (PVAN) has a predilection for kidney rather than for other solid organ transplants such as the liver. Immunosuppression is widely recognized to be a major risk factor for PVAN development. Since end-stage liver disease (ESLD) patients are immunocompromised and immunosuppression is a major cause of BK virus reactivation, we sought to evaluate BK virus replication in patients listed for liver transplantation. From April to October 2010, we enrolled 20 patients listed for liver transplantation. BK virus load was measured by quantitative real-time polymerase chain reaction on plasma and urine samples. Viremia occurred in only 1 among 20 patients. We hypothesized that in ESLD patients, the low prevalence of BK virus infection may be related to the prevalent impairment of antibacterial immunity rather than to the viral-specific one. In BK virus reactivation, not only the immunodepressive state itself, but also the specific immunologic mechanisms involved may have a role.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.02.048