The dorsomedial hypothalamus and the central pathways involved in the cardiovascular response to emotional stress

Abstract Psychological stress elicits increases in sympathetic activity accompanied by a marked cardiovascular response. Revealing the relevant central mechanisms involved in this phenomenon could contribute significantly to our understanding of the pathogenesis of stress-related cardiovascular dise...

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Bibliographic Details
Published in:Neuroscience 2011-06, Vol.184, p.64-74
Main Authors: Fontes, M.A.P, Xavier, C.H, de Menezes, R.C.A, DiMicco, J.A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
cardiovascular system
Cardiovascular System - physiopathology
central pathways
Dorsomedial Hypothalamic Nucleus - physiopathology
dorsomedial hypothalamus
Fundamental and applied biological sciences. Psychology
Neurology
Neurons - physiology
Rats
stress
Stress, Psychological - physiopathology
Sympathetic Nervous System - physiopathology
Vertebrates: nervous system and sense organs
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Summary:Abstract Psychological stress elicits increases in sympathetic activity accompanied by a marked cardiovascular response. Revealing the relevant central mechanisms involved in this phenomenon could contribute significantly to our understanding of the pathogenesis of stress-related cardiovascular diseases, and the key to this understanding is the identification of the nuclei, pathways and neurotransmitters involved in the organization of the cardiovascular response to stress. The present review will focus specifically on the dorsomedial hypothalamus, a brain region now known to play a primary role in the synaptic integration underlying the cardiovascular response to emotional stress.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2011.03.018