Sensitivity-Enhanced CMOS Phase Luminometry System Using Xerogel-Based Sensors

We present the design and implementation of a phase luminometry sensor system with improved and tunable detection sensitivity achieved using a complementary metal-oxide semiconductor (CMOS) integrated circuit. We use sol-gel derived xerogel thin films as an immobilization media to house oxygen (O 2...

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Bibliographic Details
Published in:IEEE transactions on biomedical circuits and systems 2009-10, Vol.3 (5), p.304-311
Main Authors: Lei Yao, Khan, R., Chodavarapu, V.P., Tripathi, V.S., Bright, F.V.
Format: Article
Language:English
Subjects:
Analytical chemistry
CMOS integrated circuits
CMOS sensors
luminescence sensors
Monitoring
MOS devices
optical sensors
oxygen sensors
Phase detection
phase luminometry
Phase modulation
Phased arrays
Semiconductor thin films
sensitivity enhancement
Sensor systems
Sensors
Thin film circuits
Tunable circuits and devices
xerogels
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Summary:We present the design and implementation of a phase luminometry sensor system with improved and tunable detection sensitivity achieved using a complementary metal-oxide semiconductor (CMOS) integrated circuit. We use sol-gel derived xerogel thin films as an immobilization media to house oxygen (O 2 ) responsive luminescent molecules. The sensor operates on the principal of phase luminometry wherein a sinusoidal modulation signal is used to excite the luminophores encapsulated in the porous xerogel films and the corresponding phase shift of the emission signals is monitored. The phase shift is directly related to excited state lifetimes of the luminophores which in turn are related to the concentration of the target analyte species present in the vicinity of the luminophores. The CMOS IC, which consists of a 16 times 16 high-gain phototransistor array, current-to-voltage converter, amplifier and tunable phase shift detector, consumes an average power of 14 mW with 5-V power supply operating at a 38-kHz modulation frequency. The output of the IC is a dc voltage that corresponds to the detected luminescence phase shift with respect to the excitation signal. As a prototype, we demonstrate an oxygen sensor system by encapsulating the luminophore tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) within the xerogel matrices. The sensor system showed a fast response on the order of few seconds and we obtained a detection sensitivity of 118 mV per 1% change in O 2 concentration. The system demonstrates a novel concept to tune and improve the detection sensitivity for specific concentrations of the target analyte in many biomedical monitoring applications.
ISSN:1932-4545
1940-9990
DOI:10.1109/TBCAS.2009.2022504