Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrola and melatoninainduced cardioprotection

Epidemiological studies suggest that regular moderate consumption of red wine confers cardioprotection but the mechanisms involved in this effect remain unclear. Recent studies demonstrate the presence of melatonin in wine. We propose that melatonin, at a concentration found in red wine, confers car...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pineal research 2011-05, Vol.50 (4), p.374-380
Main Authors: Lamont, Kim T, Somers, Sarin, Lacerda, Lydia, Opie, Lionel H, Lecour, Sandrine
Format: Article
Language:English
Subjects:
Vitaceae
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epidemiological studies suggest that regular moderate consumption of red wine confers cardioprotection but the mechanisms involved in this effect remain unclear. Recent studies demonstrate the presence of melatonin in wine. We propose that melatonin, at a concentration found in red wine, confers cardioprotection against ischemia-reperfusion injury. Furthermore, we investigated whether both melatonin and resveratrol protect via the activation of the newly discovered survivor activating factor enhancement (SAFE) prosurvival signaling pathway that involves the activation of tumor necrosis factor alpha (TNF alpha ) and the signal transducer and activator of transcription 3 (STAT3). Isolated perfused male mouse (wild type, TNF alpha receptor 2 knockout mice, and cardiomyocyte-specific STAT3-deficient mice) or rat hearts (Wistars) were subjected to ischemia-reperfusion. Resveratrol (2.3mg/L) or melatonin (75ng/L) was perfused for 15min with a 10-min washout period prior to an ischemia-reperfusion insult. Infarct size was measured at the end of the protocol, and Western blot analysis was performed to evaluate STAT3 activation prior to the ischemic insult. Both resveratrol and melatonin, at concentrations found in red wine, significantly reduced infarct size compared with control hearts in wild-type mouse hearts (25+/-3% and 25+/-3% respectively versus control 69+/-3%, P
ISSN:0742-3098
1600-079X
DOI:10.1111/j.1600-079X.2010.00853.x