Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa

BACKGROUND The vitamin D receptor (VDR) is expressed in human spermatozoa, and VDR-knockout mice and vitamin D (VD) deficiency in rodents results in impaired fertility, low sperm counts and a low number of motile spermatozoa. We investigated the role of activated VD (1,25(OH)2D3) in human spermatozo...

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Published in:Human reproduction (Oxford) 2011-06, Vol.26 (6), p.1307-1317
Main Authors: Blomberg Jensen, Martin, Bjerrum, Poul J., Jessen, Torben E., Nielsen, John E., Joensen, Ulla N., Olesen, Inge A., Petersen, Jørgen H., Juul, Anders, Dissing, Steen, Jørgensen, Niels
Format: Article
Language:English
Subjects:
Acrosome Reaction
Biological and medical sciences
Calcitriol - blood
Calcium - metabolism
Cross-Sectional Studies
Gynecology. Andrology. Obstetrics
Humans
Male
Medical sciences
Parathyroid Hormone - blood
Sperm Motility - drug effects
Vitamin D - blood
Vitamin D Deficiency - blood
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Summary:BACKGROUND The vitamin D receptor (VDR) is expressed in human spermatozoa, and VDR-knockout mice and vitamin D (VD) deficiency in rodents results in impaired fertility, low sperm counts and a low number of motile spermatozoa. We investigated the role of activated VD (1,25(OH)2D3) in human spermatozoa and whether VD serum levels are associated with semen quality. METHODS Cross-sectional association study of semen quality and VD serum level in 300 men from the general population, and in vitro studies on spermatozoa from 40 men to investigate the effects of VD on intracellular calcium, sperm motility and acrosome reaction. All men delivered samples for routine semen analysis and blood for measurements of follicle stimulating hormone, Inhibin B, 25-hydroxy-VD, albumin, alkaline phosphatase, calcium and parathyroid hormone (PTH). RESULTS In the association study, 44% were VD insufficient (
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/der059