The effects of atorvastatin and rosuvastatin on oxidative stress in diabetic patients

Abstract Aim Diabetes is associated with abnormalities in lipid profile and increased oxidative stress. Statins are preferred agents in diabetic patients due to their antioxidant and LDL-C lowering effects. This study is designed to compare the effects of atorvastatin and rosuvastatin on low density...

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Bibliographic Details
Published in:European journal of internal medicine 2011-06, Vol.22 (3), p.249-253
Main Authors: Koksal, Murat, Eren, Mehmet Ali, Turan, Mehmet Nuri, Sabuncu, Tevfik
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antioxidants - administration & dosage
Atorvastatin Calcium
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Female
Fluorobenzenes - administration & dosage
Heptanoic Acids - administration & dosage
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hyperlipidemia
Hyperlipidemias - complications
Hyperlipidemias - drug therapy
Hyperlipidemias - metabolism
Internal Medicine
Male
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
Pyrimidines - administration & dosage
Pyrroles - administration & dosage
Rosuvastatin Calcium
Statin
Sulfonamides - administration & dosage
Treatment Outcome
Type 2 diabetes mellitus
Young Adult
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Summary:Abstract Aim Diabetes is associated with abnormalities in lipid profile and increased oxidative stress. Statins are preferred agents in diabetic patients due to their antioxidant and LDL-C lowering effects. This study is designed to compare the effects of atorvastatin and rosuvastatin on low density lipoprotein cholesterol (LDL-C), lipid hydroperoxide (LOOH), total oxidant status (TOS) and total antioxidant capacity (TAC) in diabetic patients with hyperlipidemia. Materials and methods Sixty two patients who have type 2 diabetes mellitus with serum LDL levels more than 100 mg/dL were randomly assigned to receive atorvastatin 20 mg ( n = 31) or rosuvastatin 10 mg ( n = 31). Blood tests were performed at the beginning of the study and after three months. Results There were no statistically significant differences in the pre- and after treatment levels of the LDL-C between groups. TAC values were increased in both groups and statistically significant in the former group ( p = 0.007). There was no diferrence between the change percentages ((after treatment TAC − pretreatment TAC) / pretreatment level) of TAC between two treatment groups. The effects of two drugs on the other oxidative parameters were not significantly different. Conclusion Both atorvastatin and rosuvastatin may be helpful in reducing increased oxidative stress in diabetic patients with hyperlipidemia.
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2010.12.003