Recent Advances in Direct Catalytic Asymmetric Transformations under Proton-Transfer Conditions

Cooperative catalysis has proven to be a particularly powerful strategy for promoting stereoselective organic transformations under mild reaction conditions. The specific interactions between the catalyst components and substrates are precisely orchestrated to elicit high catalytic efficiency and ex...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2011-05, Vol.50 (21), p.4760-4772
Main Authors: Kumagai, Naoya, Shibasaki, Masakatsu
Format: Article
Language:English
Subjects:
asymmetric catalysis
atom economy
Carbon - chemistry
Catalysis
cooperative effects
Cyanides - chemistry
Imines - chemistry
Ketones - chemistry
Lewis Bases - chemistry
Molecular Structure
proton transfer
Protons
Solvents - chemistry
Stereoisomerism
tetrasubstituted stereogenic centers
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Summary:Cooperative catalysis has proven to be a particularly powerful strategy for promoting stereoselective organic transformations under mild reaction conditions. The specific interactions between the catalyst components and substrates are precisely orchestrated to elicit high catalytic efficiency and excellent control of the stereochemical course. By harnessing the power of cooperativity, various sets of stereoselective reactions proceed under mild proton‐transfer conditions with perfect atom economy. This Minireview summarizes our recent contributions to several CN and CC bond‐forming reactions in this field and related transformations. Give me an H: The sophisticated synergism of the two concepts of asymmetric catalysis and atom economy offers a truly efficient synthetic strategy for the production of requisite chemical entities with high enantiomeric purity. Recent advances in this field are highlighted, with a particular emphasis on catalytic asymmetric reactions that proceeds under proton‐transfer conditions.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201100918