Insulin resistance in tetraplegia but not in mid-thoracic paraplegia: is the mid-thoracic spinal cord involved in glucose regulation?

Controlled experimental human study. To assess insulin resistance (IR) in tetraplegia and paraplegia, and the role of the spinal cord (SC) in glucose regulation. Laboratory of Spinal Research, Loewenstein Rehabilitation Hospital. Glucose and insulin levels and the heart rate variation spectral compo...

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Bibliographic Details
Published in:Spinal cord 2011-05, Vol.49 (5), p.648-652
Main Authors: Bluvshtein, V, Korczyn, A D, Pinhas, I, Vered, Y, Gelernter, I, Catz, A
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - biosynthesis
Blood Glucose - metabolism
Cervical Vertebrae - injuries
Female
Humans
Hyperglycemia - diagnosis
Hyperglycemia - etiology
Hyperglycemia - metabolism
Insulin resistance
Insulin Resistance - physiology
Male
Middle Aged
Paraplegia - complications
Paraplegia - metabolism
Quadriplegia - complications
Quadriplegia - metabolism
Spinal Cord - metabolism
Spinal Cord - pathology
Spinal Cord Injuries - complications
Spinal Cord Injuries - metabolism
Thoracic Vertebrae - injuries
Young Adult
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Summary:Controlled experimental human study. To assess insulin resistance (IR) in tetraplegia and paraplegia, and the role of the spinal cord (SC) in glucose regulation. Laboratory of Spinal Research, Loewenstein Rehabilitation Hospital. Glucose and insulin levels and the heart rate variation spectral components LF (low frequency), HF (high frequency) and LF/HF were studied at supine rest, head-up tilt and after a standard meal in three groups: 13 healthy subjects, 7 patients with T(4)-T(6) paraplegia and 11 patients with C(4)-C(7) tetraplegia. Glucose and insulin increased significantly after the meal in all groups (P
ISSN:1362-4393
1476-5624
DOI:10.1038/sc.2010.152