Prevention of muscle fibers atrophy during gravitational unloading: The effect of l-arginine administration

Gravitational unloading results in pronounced atrophy of m.soleus. Probably, the output of NO is controlled by the muscle activity. We hypothesized that NO may be involved in the protein metabolism and increase of its concentration in muscle can prevent atrophic changes induced by gravitational unlo...

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Bibliographic Details
Published in:Acta astronautica 2011-05, Vol.68 (9), p.1486-1494
Main Authors: Kartashkina, N., Lomonosova, Y., Shevchenko, T.F., Bugrova, A.E., Turtikova, O.V., Kalamkarov, G.R., Nemirovskaya, T.L.
Format: Article
Language:English
Subjects:
Atrophy
Cytoskeletal proteins
Hindlimb suspension
l-arginine administration
NO content
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Summary:Gravitational unloading results in pronounced atrophy of m.soleus. Probably, the output of NO is controlled by the muscle activity. We hypothesized that NO may be involved in the protein metabolism and increase of its concentration in muscle can prevent atrophic changes induced by gravitational unloading. In order to test the hypothesis we applied NO donor l-arginine during gravitational unloading. 2.5-month-old male Wistar rats weighing 220–230g were divided into sedentary control group (CTR, n=7), 14-day hindlimb suspension (HS, n=7), 14 days of hindlimb suspension+ l-arginine (HSL, n=7) (with a daily supplementation of 500 mg/kg wt l-arginine) and 14 days of hindlimb suspension+ l-NAME (HSN, n=7) (90 mg/kg wt during 14 days). Cross sectional area (CSA) of slow twitch (ST) and fast twitch (FT) soleus muscle fibers decreased by 45% and 28% in the HS group ( p
ISSN:0094-5765
1879-2030
DOI:10.1016/j.actaastro.2010.02.013