KIRs and their HLA ligands in Remitting–Relapsing Multiple Sclerosis

Abstract Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we perfor...

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Bibliographic Details
Published in:Journal of neuroimmunology 2010-12, Vol.229 (1), p.232-237
Main Authors: Fusco, Caterina, Guerini, Franca Rosa, Nocera, Giustina, Ventrella, Gianluca, Caputo, Domenico, Valentino, Maria Antonietta, Agliardi, Cristina, Gallotti, Jacopo, Morra, Vincenzo Brescia, Florio, Ciro, Clerici, Mario, Lombardi, Maria Luisa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allergy and Immunology
Female
Genotype
HLA Antigens - classification
HLA Antigens - genetics
HLA Antigens - metabolism
HLA–KIR ligands
Humans
KIRs
Ligands
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - genetics
Multiple Sclerosis, Relapsing-Remitting - immunology
Multiple Sclerosis, Relapsing-Remitting - metabolism
Neurology
Odds Ratio
Receptors, KIR - genetics
Receptors, KIR - metabolism
Young Adult
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Summary:Abstract Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (py = 0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (py = 0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2010.08.004