Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a High-Fat Diet

:  The effects of oryzanol and ferulic acid on the glucose metabolism of high‐fat‐fed mice were investigated. Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high‐fat (17%) diet; HF‐O group fed with high‐fat diet supplemented with 0.5%...

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Bibliographic Details
Published in:Journal of food science 2011-01, Vol.76 (1), p.H7-H10
Main Authors: Son, Myoung Jin, Rico, Catherine W., Nam, Seok Hyun, Kang, Mi Young
Format: Article
Language:English
Subjects:
Acids
Animals
Antioxidants - therapeutic use
Biological and medical sciences
Blood Glucose - analysis
Coumaric Acids - therapeutic use
diabetes
Diet
Dietary Fats - adverse effects
Feeding. Feeding behavior
ferulic acid
Food industries
Food science
Fundamental and applied biological sciences. Psychology
Glucokinase - metabolism
Glucose
Glucose - metabolism
Glucose-6-Phosphatase - metabolism
Glycogen - metabolism
high-fat-fed mice
Hyperglycemia - blood
Hyperglycemia - metabolism
Hyperglycemia - prevention & control
Hypoglycemic Agents - therapeutic use
hypoglycemic effect
Insulin - blood
Liver - drug effects
Liver - enzymology
Liver - metabolism
Male
Metabolism
Mice
Mice, Inbred C57BL
Oils & fats
oryzanol
Phenylpropionates - therapeutic use
Phosphoenolpyruvate Carboxykinase (GTP) - metabolism
Random Allocation
Rodents
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary::  The effects of oryzanol and ferulic acid on the glucose metabolism of high‐fat‐fed mice were investigated. Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high‐fat (17%) diet; HF‐O group fed with high‐fat diet supplemented with 0.5% oryzanol; and HF‐FA group fed with high‐fat diet supplemented with 0.5% ferulic acid. All animals were allowed free access to the experimental diets and water for 7 wk. At the end of the experimental period, the HF‐O and HF‐FA groups exhibited significantly lower blood glucose level and glucose‐6‐phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) activities, and higher glycogen and insulin concentrations and glucokinase (GK) activity compared with NC and HF groups. The results of this study illustrate that both oryzanol and ferulic acid could reduce the risk of high‐fat diet‐induced hyperglycemia via regulation of insulin secretion and hepatic glucose‐regulating enzyme activities.
ISSN:0022-1147
1750-3841
DOI:10.1111/j.1750-3841.2010.01907.x