Applicability of equine hydroxyapatite collagen (eHAC) bone blocks for lateral augmentation of the alveolar crest. A histological and histomorphometric analysis in rats

Abstract This study assessed the mechanical characteristics, biocompatibility and osteoconductive properties of an equine hydroxyapatite collagen (eHAC) bone block when applied as a bone substitute for lateral augmentation of rat mandible. 96 rats underwent lateral augmentation of the mandible, usin...

Full description

Saved in:
Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2011-05, Vol.40 (5), p.533-542
Main Authors: Zecha, P.J, Schortinghuis, J, van der Wal, J.E, Nagursky, H, van den Broek, K.C, Sauerbier, S, Vissink, A, Raghoebar, G.M
Format: Article
Language:English
Subjects:
Absorbable Implants
alveolar crest
Alveolar Ridge Augmentation - instrumentation
Alveolar Ridge Augmentation - methods
Animals
Bio-Oss
Biocompatible Materials - therapeutic use
Biological and medical sciences
Biomechanical Phenomena
bone graft
Bone Matrix - transplantation
Bone Screws
Bone Substitutes - therapeutic use
Bone Transplantation - methods
Collagen - therapeutic use
Dentistry
Durapatite - therapeutic use
eHAC
Horses
Inflammation
lateral augmentation
Male
Mandible - pathology
Mandible - surgery
Medical sciences
Membranes, Artificial
Minerals - therapeutic use
Osteogenesis - physiology
Otorhinolaryngology. Stomatology
Random Allocation
Rats
Rats, Sprague-Dawley
Surgery
Time Factors
Tissue Scaffolds
Transplantation, Autologous
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract This study assessed the mechanical characteristics, biocompatibility and osteoconductive properties of an equine hydroxyapatite collagen (eHAC) bone block when applied as a bone substitute for lateral augmentation of rat mandible. 96 rats underwent lateral augmentation of the mandible, using two substitute bone blocks (eHAC or Bio-Oss® spongiosa) or autologous bone grafts. Signs of inflammation, amount of bone formation and ingrowth of bone into the bone blocks were assessed at 1 and 3 months. eHAC blocks were mechanically rigid and could be fixed firmly and easily. Bio-Oss® spongiosa blocks were brittle and fixation was difficult. eHAC and Bio-Oss® spongiosa blocks were biocompatible and induced few or no signs of inflammation. Inflammation prevalence between the groups was not statistically different. Bone formation and bone growth into the blocks was significantly higher in eHAC than Bio-Oss® spongiosa blocks, but lower than in autologous bone grafts (after 1 and 3 months). Regression analysis showed that the autologous bone graft predicted new bone formation at both time points. The eHAC block was only a predictor at 1 month; a trend was found at 3 months. The application of biodegradable membranes was not related to more bone ingrowth.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2011.01.007