Usefulness of Total Lymphocyte Count as Predictor of Outcome in Patients With Chronic Heart Failure

Low lymphocyte count has been considered a predictive marker of unfavorable outcomes for patients with heart failure (HF). Baseline blood samples for complete blood counts, differential counts, renal function tests. and lipid profile were prospectively obtained to assess the association between lymp...

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Bibliographic Details
Published in:The American journal of cardiology 2011-05, Vol.107 (9), p.1353-1356
Main Authors: Charach, Gideon, MD, Grosskopf, Itamar, MD, Roth, Arie, MD, Afek, Arnon, MD, Wexler, Dov, MD, Sheps, David, MD, Weintraub, Moshe, MD, Rabinovich, Alexander, MD, Keren, Gad, MD, George, Jacob, MD
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Cardiovascular
Chronic Disease
Clinical outcomes
Female
Heart
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Lymphocyte Count
Lymphocytes
Male
Medical sciences
Predictive Value of Tests
Regression analysis
Regularization methods
Risk Factors
Severity of Illness Index
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Summary:Low lymphocyte count has been considered a predictive marker of unfavorable outcomes for patients with heart failure (HF). Baseline blood samples for complete blood counts, differential counts, renal function tests. and lipid profile were prospectively obtained to assess the association between lymphocyte count and clinical outcomes in 305 patients with HF (average New York Heart Association [NYHA] class 2.8). The mean follow-up duration was 4.7 years (range 8 months to 8.4 years), and 111 patients (36%) died during the follow-up period. The mean lymphocyte count for the group was 1,803.64 ± 740.3, and the mean left ventricular ejection fraction (LVEF) was 37%. Patients with low lymphocyte counts (
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2010.12.049