Primary Adenocarcinoma in a Kidney Allograft: A Case Report and Review of the Literature

Abstract De novo tumors are common complications after solid organ transplantation. Lymphoma and skin cancers are the most frequently observed malignancies. However, graft carcinomas can be observed to be five times more frequent after kidney transplantation compared to their incidence in the genera...

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Bibliographic Details
Published in:Transplantation proceedings 2011-03, Vol.43 (2), p.660-662
Main Authors: Yaich, S, El'Aoud, N, Zaghdane, S, Chabchoub, K, Charfeddine, K, Kharrat, M, Mhiri, M.N, Hachicha, J
Format: Article
Language:English
Subjects:
Adenocarcinoma - complications
Adenocarcinoma - etiology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Kidney Neoplasms - complications
Kidney Neoplasms - etiology
Kidney Transplantation - adverse effects
Medical sciences
Middle Aged
Postoperative Complications
Renal Dialysis
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Treatment Outcome
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Summary:Abstract De novo tumors are common complications after solid organ transplantation. Lymphoma and skin cancers are the most frequently observed malignancies. However, graft carcinomas can be observed to be five times more frequent after kidney transplantation compared to their incidence in the general population. We report a case of a 49-year-old female who developed an early adenocarcinoma of the graft as revealed by acute renal failure. She underwent transplantectomy and chemotherapy with hemodialysis therapy. Carcinoma of the graft is a rare but serious complication usually occurring late after transplantation. Close monitoring of a kidney recipient using abdominal ultrasound may detect this complication at early stages, which may improve the prognosis. Similarly, good screening of donors may prevent tumor transmission.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.01.074