Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates

Mesoporous silica nanoparticles can be modified to perform on-demand stimuli-responsive dosing of therapeutic molecules. The silica network was loaded with iron oxide superparamagnetic nanocrystals, providing the potential to perform targeting and magnetic resonance imaging. Single-stranded DNA was...

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Bibliographic Details
Published in:ACS nano 2011-02, Vol.5 (2), p.1259-1266
Main Authors: Ruiz-Hernández, Eduardo, Baeza, Alejandro, Vallet-Regí, María
Format: Article
Language:English
Subjects:
Antineoplastic Agents - metabolism
Base Sequence
DNA - chemistry
DNA - genetics
Drug Delivery Systems - methods
Ferric Compounds - chemistry
Magnetics
Models, Molecular
Nanoparticles - chemistry
Neoplasms - metabolism
Nucleic Acid Conformation
Oligodeoxyribonucleotides - chemistry
Oligodeoxyribonucleotides - genetics
Porosity
Silicon Dioxide - chemistry
Temperature
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Summary:Mesoporous silica nanoparticles can be modified to perform on-demand stimuli-responsive dosing of therapeutic molecules. The silica network was loaded with iron oxide superparamagnetic nanocrystals, providing the potential to perform targeting and magnetic resonance imaging. Single-stranded DNA was immobilized onto the material surface. The complementary DNA sequence was then attached to magnetic nanoparticles. The present work demonstrates that DNA/magnetic nanoparticle conjugates are able to cap the pores of the magnetic silica particles upon hybridization of both DNA strands. Progressive double-stranded DNA melting as a result of temperature increase gave rise to uncapping and the subsequent release of a mesopore-filled model drug, fluorescein. The reversibility of DNA linkage results in an “on−off” release mechanism. Moreover, the magnetic component of the whole system allows reaching hyperthermic temperatures (42−47 °C) under an alternating magnetic field. This feature leaves open the possibility of a remotely triggered drug delivery. Furthermore, due to its capacity to increase the temperature of the surrounding media, this multifunctional device could play an important role in the development of advanced drug delivery systems for thermochemotherapy against cancer.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn1029229