Influence of glycemic control on tympanic membrane healing in diabetic rats

Objectives/Hypothesis: It is generally assumed that glycemic control in diabetic patients is important in optimizing wound healing. The goal of this study was to examine tympanic membrane (TM) wound healing in spontaneously diabetic rats depending on the diabetic metabolic state compared to nondiabe...

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Bibliographic Details
Published in:The Laryngoscope 2011-04, Vol.121 (4), p.823-827
Main Authors: Kaftan, Holger, Reuther, Lars, Miehe, Bärbel, Hosemann, Werner, Klöting, Ingrid
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - metabolism
diabetes
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - genetics
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - pathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fructosamine - blood
glycemic control
Level of Evidence: 1b
Medical sciences
Otorhinolaryngology. Stomatology
rat
Rats
Rats, Inbred BB
Tympanic membrane
Tympanic Membrane - pathology
Tympanic Membrane Perforation - pathology
wound healing
Wound Healing - physiology
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Summary:Objectives/Hypothesis: It is generally assumed that glycemic control in diabetic patients is important in optimizing wound healing. The goal of this study was to examine tympanic membrane (TM) wound healing in spontaneously diabetic rats depending on the diabetic metabolic state compared to nondiabetic control animals. Study Design: Prospective controlled study in experimental animals. Methods: Right‐sided myringotomy was performed in 20 normoglycemic rats, 17 well‐compensated, and 23 poorly compensated diabetic rats. TMs were observed for a total of 3 weeks. Effect of diabetic metabolic state on the healing of the TMs was evaluated by closure rates and histology. Results: Diabetic rats showed a significant delay in TM wound healing compared to the control group, but there were no significant differences between both diabetes groups. Conclusions: Glycemic control does not influence TM wound repair in an animal model of type 1 diabetes. Laryngoscope, 2011
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.21426