A comparison of single-voxel clinical in vivo hepatic 31P MR spectra acquired at 1.5 and 3.0 Tesla in health and diseased states

With the increasing availability of human MR scanners at various field strengths, the optimal field strength for in vivo clinical MR studies of the liver has become a focus of attention. Comparison between results at 3.0 and 1.5 T is of particular clinical interest, especially for multicentre studie...

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Bibliographic Details
Published in:NMR in biomedicine 2011-04, Vol.24 (3), p.231-237
Main Authors: Wylezinska, Marzena, Cobbold, Jeremy F.L., Fitzpatrick, Julie, McPhail, Mark J.W., Crossey, Mary M.E., Thomas, Howard C., Hajnal, Joseph V., Vennart, William, Cox, I. Jane, Taylor-Robinson, Simon D.
Format: Article
Language:English
Subjects:
Adult
Female
field strength comparison
Humans
liver
Liver - metabolism
Liver - pathology
Liver diseases
Liver Diseases - metabolism
Liver Diseases - physiopathology
Magnetic fields
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Male
Middle Aged
MRS
N.M.R
Nuclear Overhauser effect
phosphodiesters
Phospholipids
phosphomonoesters
Phosphorus Isotopes - metabolism
Protons
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Summary:With the increasing availability of human MR scanners at various field strengths, the optimal field strength for in vivo clinical MR studies of the liver has become a focus of attention. Comparison between results at 3.0 and 1.5 T is of particular clinical interest, especially for multicentre studies. For MRS studies, higher field strengths should be advantageous, because improved sensitivity and chemical shift dispersion are expected. We report a comparison between single‐voxel hepatic proton‐decoupled 31P MRS performed at 1.5 and 3.0 T in the same subjects using similar methodologies. Twelve healthy volunteers and 15 patients with chronic liver disease were studied. Improved spectral resolution was achieved using proton decoupling, and there was an improvement (21%) in the signal‐to‐noise ratio (SNR) of the phosphomonoester (PME) resonance at 3.0 T relative to 1.5 T. There was no significant change in nuclear Overhauser effects for PME or phosphodiesters (PDEs) between the two field strengths. The T1 value of PDE was significantly longer at 3 T, although there was no significant change in the T1 value of PME. There was no significant difference in the mean PME/PDE ratios for either the control or patient groups at both 1.5 and 3.0 T, but there was a small positive mean difference in PME/PDE at 3.0 T on pairwise testing between field strengths (+ 0.05, p 
ISSN:0952-3480
1099-1492
1099-1492
DOI:10.1002/nbm.1578