Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children

Abstract Objective Improvement of hemoglobin and serum retinol and facilitation of the mobilization of iron storage were achieved with a multiple-micronutrient–fortified diet in preschoolers for 6 mo in a suburb of Chongqing, China. We investigated whether fortification with multiple micronutrients...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2011-04, Vol.27 (4), p.428-434
Main Authors: Chen, Ke, Ph.D, Zhang, Xuan, Ph.D, Li, Ting-yu, M.D, Chen, Li, Ph.D, Wei, Xiao-ping, M.D, Qu, Ping, M.D, Liu, You-xue, Ph.D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Children & youth
China - epidemiology
Cough
Diarrhea - epidemiology
Diarrhea - prevention & control
Dietary Supplements
Drug Therapy, Combination
Feeding. Feeding behavior
Female
Fever
Food, Fortified
Fortification
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Humans
Incidence
Infectious morbidity
Iron, Dietary - therapeutic use
Male
Micronutrients - therapeutic use
Mortality
Multiple micronutrients
Preschool children
Respiratory Tract Infections - complications
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - prevention & control
Rhinitis
Socioeconomic factors
Spices
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin A
Vitamin A - therapeutic use
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Summary:Abstract Objective Improvement of hemoglobin and serum retinol and facilitation of the mobilization of iron storage were achieved with a multiple-micronutrient–fortified diet in preschoolers for 6 mo in a suburb of Chongqing, China. We investigated whether fortification with multiple micronutrients in a diet for preschool children results in changes in children's infectious morbidity compared with diets fortified solely with vitamin A and with vitamin A plus iron. Methods From December 2005 to June 2006, 226 2- to 6-y-old preschool children were recruited from three nurseries randomly assigned to three different fortified-diet groups for 6 mo. Group I was fortified with vitamin A; groups II and III were fortified with vitamin A plus iron and vitamin A plus iron, thiamine, riboflavin, folic acid, niacinamide, zinc, and calcium, respectively. The secondary functional outcomes, morbidity of diarrhea and respiratory infection, were collected during supplementation. Results The groups were comparable concerning compliance and loss to follow-up. There was evidence of a lower incidence rate of respiratory-related illnesses, diarrhea-related illness, fewer symptoms of runny nose, cough, and fever, and shorter duration of respiratory-related illnesses and cough for children in group III compared with children in groups I and II. However, there was no significantly or clinically important difference between children in groups I and II. Conclusion The beneficial effects on infectious morbidity over 6 mo, in addition to some biochemical improvements, highlight the potential of this micronutrient-fortified seasoning powder supplied in a diet for preschool children.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2010.04.004