Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation

The aim of our study was to assess the blood concentrations of some trace elements and melatonin (MLT) in patients with intervertebral disc herniation (IDH) and to investigate the interaction of histological and biochemical degeneration findings with aging. The present study was carried out on 13 su...

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Bibliographic Details
Published in:Biological trace element research 2006-02, Vol.109 (2), p.123-134
Main Authors: Turgut, Mehmet, Yenisey, Cigdem, Akyüz, Orhan, Ozsunar, Yelda, Erkus, Muhan, Biçakçi, Tuncay
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging
Biochemistry
Blood
Brain
Calcification
Calcinosis
Collagen - analysis
Computed tomography
Data Interpretation, Statistical
Data processing
Female
Geriatrics
Histology
Humans
Hydroxyproline
Hydroxyproline - analysis
Intervertebral Disc - chemistry
Intervertebral Disc - pathology
Intervertebral Disc Displacement - blood
Intervertebral Disc Displacement - pathology
Intervertebral discs
Lumbar Vertebrae - pathology
Magnesium
Magnesium - blood
Magnetic Resonance Imaging
Male
Medical research
Melatonin
Melatonin - blood
Middle Aged
Neurodegeneration
Nighttime
Pineal gland
Pineal Gland - diagnostic imaging
Spectrophotometry, Atomic
Spine
Spine (lumbar)
Tomography, X-Ray Computed
Trace elements
Zinc
Zinc - blood
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Summary:The aim of our study was to assess the blood concentrations of some trace elements and melatonin (MLT) in patients with intervertebral disc herniation (IDH) and to investigate the interaction of histological and biochemical degeneration findings with aging. The present study was carried out on 13 subjects (8 women and 5 men) diagnosed with IDH. They were divided into three groups according to their ages. Nighttime serum MLT, zinc (Zn), and magnesium (Mg) levels were determined in all patients. In addition, computed tomography (CT) scan of the brain and magnetic resonance imaging examination of the lumbar spine were obtained in this study. The Zn level and Zn/Mg ratio showed a decline in patients with IDH with aging, whereas the serum Mg level and tissue hydroxyproline content increased. A positive correlation between serum Zn and MLT concentrations was found (r=0.104, p=0.734). In addition, there was a positive correlation between serum Zn level and Zn/Mg ratio (r=0.835 and p
ISSN:0163-4984
1559-0720
0163-4984
DOI:10.1385/BTER:109:2:123