The Application of Tissue Engineering Procedures to Repair the Larynx

Joel C. Kahane The University of Memphis, Memphis, TN Peter J. Hillsamer Lafayette Otolaryngology Associates, Lafayette, IN Annie S. Lee Stephen F. Badylak University of Pittsburgh, Pittsburgh, PA Contact author: Joel C. Kahane, School of Audiology and Speech-Language Pathology, The University of Me...

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Published in:Journal of speech, language, and hearing research language, and hearing research, 2006-02, Vol.49 (1), p.194-208
Main Authors: Ringel, Robert L, Kahane, Joel C, Hillsamer, Peter J, Lee, Annie S, Badylak, Stephen F
Format: Article
Language:English
Subjects:
Analysis
Anatomy
Animals
Biological organs
Biological Sciences
Care and treatment
Cellular biology
Congenital Impairments
Cytology
Dogs
Engineering
Female
Hearing
Histology
Human Body
Human tissues
Laryngectomy
Laryngology
Larynx
Larynx - surgery
Matrix
Medicine
Methods
Models, Animal
Physiology
Recovery of Function
Science Experiments
Speech
Speech Communication
Speech disorders
Surgery
Swine
Technology
Tissue culture
Tissue engineering
Tissue Engineering - methods
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Summary:Joel C. Kahane The University of Memphis, Memphis, TN Peter J. Hillsamer Lafayette Otolaryngology Associates, Lafayette, IN Annie S. Lee Stephen F. Badylak University of Pittsburgh, Pittsburgh, PA Contact author: Joel C. Kahane, School of Audiology and Speech-Language Pathology, The University of Memphis, 807 Jefferson Avenue, Memphis, TN 38105. Email: jckahane{at}memphis.edu The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice, and hearing. The present manuscript describes a study that was conducted in which a biologic scaffold derived from porcine (pig) extracellular matrix (ECM) was used to repair the defect following a hemilaryngectomy procedure in dogs. The ECM-augmented repair was compared with a control standard strap muscle (STM) procedure. The animals were sacrificed after 24 weeks at which time anatomic and histologic analyses were conducted. The ECM repair resulted in a macroscopic and microscopic reconstruction of laryngeal tissue that was superior to that observed with the STM procedure. The importance of regenerated tissue having the same structural and functional characteristics of native tissue is emphasized. A discussion of the mechanisms of ECM remodeling is presented along with the implications of such remodeling in the repair of laryngeal structures. KEY WORDS: extracellular matrix (ECM), tissue engineering, tissue grafting, hemilaryngectomy repair, laryngeal anatomy, morphology, histology CiteULike     Connotea     Del.icio.us     Digg     Facebook     Reddit     Technorati     Twitter     What's this?
ISSN:1092-4388
1558-9102
DOI:10.1044/1092-4388(2006/016)