Colchicine Modulates Oxidative Stress in Serum and Leucocytes from Remission Patients with Family Mediterranean Fever Through Regulation of Ca2+ Release and the Antioxidant System

We investigated the effects of colchicine on oxidative stress and Ca 2+ release in serum and polymorphonuclear leucocytes (PMNs) of Familial Mediterranean Fever (FMF) patients with attack, remission and unremission periods. Eighteen FMF patients and six age-matched healthy subjects in four groups we...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of membrane biology 2011-03, Vol.240 (1), p.55-62
Main Authors: Şahin, Mehmet, Cihangir Uğuz, A., Demirkan, Halil, Nazıroğlu, Mustafa
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
beta Carotene - metabolism
Biochemistry
Biomedical and Life Sciences
Calcium - metabolism
Case-Control Studies
Colchicine - administration & dosage
Colchicine - therapeutic use
Familial Mediterranean Fever - blood
Familial Mediterranean Fever - drug therapy
Familial Mediterranean Fever - pathology
Female
Glutathione Peroxidase - metabolism
Gout Suppressants - administration & dosage
Gout Suppressants - therapeutic use
Human Physiology
Humans
Ion Transport - drug effects
Life Sciences
Lipid Peroxidation - drug effects
Male
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine - pharmacology
Neutrophils - metabolism
Neutrophils - pathology
Oxidative Stress - drug effects
Remission Induction
Serum - chemistry
Vitamin E - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the effects of colchicine on oxidative stress and Ca 2+ release in serum and polymorphonuclear leucocytes (PMNs) of Familial Mediterranean Fever (FMF) patients with attack, remission and unremission periods. Eighteen FMF patients and six age-matched healthy subjects in four groups were used. The first group was a control. The second group included patients with active FMF. The third and fourth groups were patients with remission and unremission, respectively. Colchicine (1.5 mg/day) was given to the third and fourth groups for 1 month. PMN cells, serum lipid peroxidation and intracellular Ca 2+ -release levels in the attack and unremission groups were higher than in those in controls, although they were lower in the remission group than in the attack group. Serum vitamin E and β-carotene concentrations were higher in the remission group than in the control and attack groups. However, PMN, serum lipid peroxidation and Ca 2+ -release levels were further increased in the unremission group compared to the attack group. Glutathione peroxidase, reduced glutathione and vitamin A values in the four groups did not change by FMF and colchicine. In conclusion, we observed that colchicine induced protective effects on oxidative stress by modulating vitamin E, β-carotene and Ca 2+ -release levels in FMF patients with a remission period.
ISSN:0022-2631
1432-1424
DOI:10.1007/s00232-011-9342-1