Bacteria-based AND logic gate: a decision-making and self-powered biosensor

We developed a bacteria-based AND logic gate using a Pseudomonas aeruginosa lasI/rhlI double mutant with two quorum-sensing signaling molecules as the input signals. We showed a distinct electrical output signal, despite the complexity and continuous regulation of metabolic reactions of living cells...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (11), p.3060-3062
Main Authors: Li, Zhongjian, Rosenbaum, Miriam A, Venkataraman, Arvind, Tam, Tsz Kin, Katz, Evgeny, Angenent, Largus T
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - chemistry
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biosensing Techniques
Electrochemical Techniques
Electrodes
Ligases - chemistry
Ligases - genetics
Ligases - metabolism
Mutation
Phenazines - chemistry
Pseudomonas aeruginosa - metabolism
Quorum Sensing - physiology
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:We developed a bacteria-based AND logic gate using a Pseudomonas aeruginosa lasI/rhlI double mutant with two quorum-sensing signaling molecules as the input signals. We showed a distinct electrical output signal, despite the complexity and continuous regulation of metabolic reactions of living cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc05037g