Renal transplantation for nephrogenic systemic fibrosis: a case report and review of the literature

Nephrogenic systemic fibrosis (NSF) is a rare fibrosing disorder described among patients with renal disease. Currently, no standard therapy exists, although therapeutic modalities have included plasmapheresis, extracorporeal photopheresis, sodium thiosulphate, imatinib and renal transplantation. We...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2011-03, Vol.26 (3), p.1099-1101
Main Authors: CUFFY, Madison C, SINGH, Mansher, FORMICA, Richard, SIMMONS, Evans, ABU ALFA, Ali K, CARLSON, Kacie, GIRARDI, Michael, COWPER, Shawn E, KULKARNI, Sanjay
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Emergency and intensive care: renal failure. Dialysis management
Female
Graft Rejection - etiology
Humans
Intensive care medicine
Kidney Transplantation - adverse effects
Medical sciences
Middle Aged
Nephrogenic Fibrosing Dermopathy - therapy
Skin Diseases - etiology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Treatment Outcome
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Summary:Nephrogenic systemic fibrosis (NSF) is a rare fibrosing disorder described among patients with renal disease. Currently, no standard therapy exists, although therapeutic modalities have included plasmapheresis, extracorporeal photopheresis, sodium thiosulphate, imatinib and renal transplantation. We describe a patient with NSF who was physically debilitated and underwent renal transplantation. After transplantation, the patient's lesions improved clinically, and the patient was ambulatory. Despite developing worsening renal function, her lesions remained unchanged. We conclude that renal transplantation improves symptoms of NSF, and believe that in patients with NSF, careful consideration should be made for early renal transplantation.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfq693