Acute dengue virus myositis: A report of seven patients of varying clinical severity including two cases with severe fulminant myositis

Abstract Background Acute dengue myositis is characterized by fever and myalgia (with or without muscle weakness). Method The 7 cases of acute dengue myositis were retrospectively evaluated in the present study. Dengue myositis was diagnosed on the basis of a clinical picture consistent with the inf...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 2011-01, Vol.300 (1), p.14-18
Main Authors: Paliwal, Vimal Kumar, Garg, Ravindra Kumar, Juyal, Ratish, Husain, Nuzhat, Verma, Ritu, Sharma, Pawan Kumar, Verma, Rajesh, Singh, Maneesh Kumar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child, Preschool
Creatine Kinase - blood
Creatine phosphokinase
Dengue - blood
Dengue - complications
Dengue - diagnosis
Dengue virus
Dengue Virus - immunology
Female
Human viral diseases
Humans
Immunoglobulin M - blood
Infectious diseases
Male
Medical sciences
Myalgia
Myositis
Myositis - blood
Myositis - complications
Myositis - virology
Neurology
Viral diseases
Viral diseases of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Acute dengue myositis is characterized by fever and myalgia (with or without muscle weakness). Method The 7 cases of acute dengue myositis were retrospectively evaluated in the present study. Dengue myositis was diagnosed on the basis of a clinical picture consistent with the infection, elevated creatine phosphokinase, normal CSF, positive serum IgM for dengue virus, and the exclusion of other causes. Results The mean age of patients was 19.4 (range 3–40) years. Majority (5) of the patients were male. In our series 3 of the cases suffered from fulminant myositis. They were characterized by generalized weaknesses which included the respiratory muscles. All the 3 patients had markedly elevated creatine phosphokinase levels (ranging from 16,590 to 117,200 IU/L). Two patients suffering from fulminant myositis required mechanical ventilation. However, they succumbed to their illnesses. The third patient showed signs of improvement. One case had paraparesis and an elevated creatine phosphokinase level. However, a spontaneous complete recovery was observed. The remaining 3 cases had quadriparesis with trunk and neck weaknesses, sparing of respiratory muscles, creatine phosphokinase levels up to 3000 U/L. However, a complete recovery was observed in these patients within 4 weeks. Conclusion To conclude, early respiratory involvement, high creatine phosphokinase values, and severe myalgia suggest a severe form of dengue myositis.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2010.10.022