Effects of dietary copper exposure on accumulation, growth, and hematological parameters in Cyprinus carpio

The influence of dietary copper (Cu) exposure on accumulation, growth, and hematological parameters was investigated in Cyprinus carpio after sub-chronic ingestion of 0, 250, 500, 750 or 1000 mg kg −1 for 60 days. The profile of Cu accumulation among tissues in C. carpio was dependent on the exposur...

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Bibliographic Details
Published in:Toxicological and environmental chemistry 2010-11, Vol.92 (10), p.1865-1878
Main Authors: Al-Akel, A.S., Al-Balawi, H.F. Alkahem, Al-Misned, F., Mahboob, Shahid, Ahmad, Z., Suliman, E.M.
Format: Article
Language:English
Subjects:
Carp
Copper
Cprinus carpio
Cyprinus carpio
Deoxyribonucleic acid
dietary copper
DNA
Freshwater
growth
hematological parameters
Intestines
Liver
Magnesium
Muscles
Physical growth
Physiology
Ribonucleic acid
Ribonucleic acids
RNA
RNA : DNA ratio
Serums
Tissues
Toxicity
Transaminases
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Summary:The influence of dietary copper (Cu) exposure on accumulation, growth, and hematological parameters was investigated in Cyprinus carpio after sub-chronic ingestion of 0, 250, 500, 750 or 1000 mg kg −1 for 60 days. The profile of Cu accumulation among tissues in C. carpio was dependent on the exposure period and Cu concentration. Liver of C. carpio was the predominant storage tissue and the order of Cu accumulation in tissues was liver > intestine > gill > kidney > muscle. Cu concentration at >125 mg kg −1 reduced growth rate, and was inversely related to growth. The RNA : DNA ratios were not affected by exposure and there was no correlation between growth rate and RNA : DNA ratio in liver and muscle. There were no significant effects of exposure on blood parameters except for magnesium. Cu exposure time and dose increased the serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) activity levels.
ISSN:0277-2248
1029-0486
DOI:10.1080/02772248.2010.486230