The quality of life in patients after peripheral bypass surgery deteriorates at long-term follow-up

Objective We aimed to study the long-term development of health-related quality of life (HR-QoL) in patients with peripheral arterial disease after they underwent peripheral bypass surgery and to evaluate the influence of adverse vascular events that occurred during follow-up. Methods We compared cu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of vascular surgery 2011-03, Vol.53 (3), p.643-650
Main Authors: van Hattum, Eline S., MD, PhD, Tangelder, Marco J.D., MD, PhD, Lawson, James A., MD, PhD, Moll, Frans L., MD, PhD, Algra, Ale, MD, PhD
Format: Article
Language:English
Subjects:
Administration, Oral
Aged
Aged, 80 and over
Anticoagulants - administration & dosage
Aspirin - administration & dosage
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Female
Follow-Up Studies
Humans
Lower Extremity - blood supply
Male
Medical sciences
Middle Aged
Netherlands
Peripheral Arterial Disease - psychology
Peripheral Arterial Disease - surgery
Pharmacology. Drug treatments
Platelet Aggregation Inhibitors - administration & dosage
Quality of Life
Randomized Controlled Trials as Topic
Retrospective Studies
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surveys and Questionnaires
Time Factors
Treatment Outcome
Vascular Grafting - adverse effects
Vascular Grafting - psychology
Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective We aimed to study the long-term development of health-related quality of life (HR-QoL) in patients with peripheral arterial disease after they underwent peripheral bypass surgery and to evaluate the influence of adverse vascular events that occurred during follow-up. Methods We compared current HR-QoL scores with previous measurements in patients who participated in the Dutch Bypass and Oral Anticoagulants or Aspirin (BOA) Study between 1995 and 1998 after they underwent infrainguinal bypass surgery. Patients from six centers that contributed most to the Dutch BOA Study (n = 482) were followed up retrospectively from 1995 up to 2009. Results At a mean follow-up of 11 years since BOA randomization, 165 of the 482 patients were alive of whom 123 (75%) completed the EQ-5D and RAND-36 questionnaires. Fifty-three patients completed the questionnaires three times: at BOA entry, at BOA close-out, and at BOA long-term follow-up. In these patients the HR-QoL scores decreased over time, especially for the physical health dimension. In comparison with the general population, matched for age and gender, the HR-QoL scores at both BOA entry and long-term follow-up were substantially lower, even if the patient's graft was patent and no other vascular events had occurred. The occurrence of an adverse vascular event worsened the physical health state further. Conclusions The physical HR-QoL in patients with peripheral arterial disease ( PAD ) after peripheral bypass surgery was highly impaired, independent of graft patency, and deteriorated further over time. An adverse vascular event worsened the physical health state and underlined the importance of atherosclerotic risk management as well as stimulation of physical activity in patients with peripheral arterial disease to preserve HR-QoL.
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2010.09.021