Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks

Procyanidin oligomers in Cinnamon are thought to be responsible for the biological activity in the treatment of diabetes mellitus (DM). To clarify types of procyanidin oligomers in different Cinnamon species and investigate their different effects, the present study investigated procyanidin oligomer...

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Published in:Phytomedicine (Stuttgart) 2011-02, Vol.18 (4), p.298-302
Main Authors: Lu, Zhaolian, Jia, Qi, Wang, Rui, Wu, Ximin, Wu, Yingchun, Huang, Caiguo, Li, Yiming
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Antioxidants - therapeutic use
Biflavonoids - pharmacology
Biflavonoids - therapeutic use
Blood Glucose - drug effects
Blood sugar
Care and treatment
Catechin - pharmacology
Catechin - therapeutic use
Chemical properties
Cinnamomum aromaticum - chemistry
Cinnamomum cassia
Cinnamomum japonica
Cinnamon
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Type 2 - drug therapy
Diagnosis
Glucose Tolerance Test
Health aspects
Hep G2 Cells
Humans
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin
Insulin - blood
Insulin Resistance
Male
Measurement
Mice
Oligomers
Phytotherapy
Plant Bark - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
Proanthocyanidins - pharmacology
Proanthocyanidins - therapeutic use
Procyanidin oligomers
Properties
Streptozocin - pharmacology
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Summary:Procyanidin oligomers in Cinnamon are thought to be responsible for the biological activity in the treatment of diabetes mellitus (DM). To clarify types of procyanidin oligomers in different Cinnamon species and investigate their different effects, the present study investigated procyanidin oligomers in polyphenolic oligomer-rich extracts of three Cinnamon samples by LC–MS methods, and their hypoglycemic activities were detected in vivo and in vitro. The results showed that two of the three samples from Cinnamomum cassia were rich in B-type procyanidin oligomers, and the other sample was rich in A-type procyanidin oligomers. The Cinnamon extracts were administered at doses of 200 and 300 mg/kg body wt. in high-fat diet-fed and low-dose streptozotocin (STZ)-induced diabetic mice for 14 days. The results showed that blood glucose concentrations were significantly decreased in all Cinnamon extract groups compared with the control group ( p < 0.05). Administration of the Cinnamon extracts significantly increased the consumption of extracellular glucose in insulin-resistant HepG2 cells and normal HepG2 cells compared with the control group. These results suggest that both A- and B-type procyanidin oligomers in different Cinnamon species have hypoglycemic activities and may improve insulin sensitivity in type 2 DM.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2010.08.008