Propofol and children - what we know and what we do not know

Summary The pharmacokinetics of propofol are relatively well described in the pediatric population. Recent work has confirmed the validity of allometric scaling for predicting propofol disposition across different species and for describing pediatric ontogenesis. In the first year of life, allometri...

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Bibliographic Details
Published in:Pediatric anesthesia 2011-03, Vol.21 (3), p.247-254
Main Authors: Rigby-Jones, Ann E., Sneyd, J. Robert
Format: Article
Language:English
Subjects:
Algorithms
Anesthesia, Intravenous
Anesthetics, Intravenous - administration & dosage
Anesthetics, Intravenous - pharmacokinetics
Body Weight
Child
children
Consciousness Monitors
Drug Delivery Systems
Humans
Infant, Newborn
Infusions, Intravenous
pharmacodynamics
pharmacokinetics
propofol
Propofol - administration & dosage
Propofol - pharmacokinetics
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Summary:Summary The pharmacokinetics of propofol are relatively well described in the pediatric population. Recent work has confirmed the validity of allometric scaling for predicting propofol disposition across different species and for describing pediatric ontogenesis. In the first year of life, allometric models require adjustment to reflect ontogeny of maturation. Pharmacodynamic data for propofol in children are scarcer, because of practical difficulties in data collection and the limitations of currently available depth of anesthesia monitors for pediatric use. Hence, questions relating to the comparative sensitivity of children to propofol, and differences in time to peak effect relative to adults, remain unanswered. Keo half‐lives have been determined for pediatric kinetic models using time to peak effect techniques but are not currently incorporated into commercially available target‐controlled infusion pumps.
ISSN:1155-5645
1460-9592
DOI:10.1111/j.1460-9592.2010.03454.x