Vitamin D levels in children with recurrent tonsillitis

Abstract Aim Although recurrent tonsillitis can be the consequence of defects in immune system, the exact etiology of recurrent tonsillitis is not clear. In this study, our aim was to determine the serum vitamin D levels and vitamin D receptor polymorphism among children undergone tonsillectomy due...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2011-03, Vol.75 (3), p.364-367
Main Authors: Aydın, Salih, Aslan, İsmet, Yıldız, İsmail, Ağaçhan, Bedia, Toptaş, Bahar, Toprak, Sadık, Değer, Kemal, Oktay, Mehmet Faruk, Ünüvar, Emin
Format: Article
Language:English
Subjects:
Case-Control Studies
Cathelicidin
Child
Child, Preschool
Children
Defensin
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infection
Male
Otolaryngology
Pediatrics
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
Receptors, Calcitriol - genetics
Recurrence
Recurrent tonsillitis
Tonsillectomy
Tonsillitis - blood
Tonsillitis - genetics
Tonsillitis - surgery
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:Abstract Aim Although recurrent tonsillitis can be the consequence of defects in immune system, the exact etiology of recurrent tonsillitis is not clear. In this study, our aim was to determine the serum vitamin D levels and vitamin D receptor polymorphism among children undergone tonsillectomy due to the recurrent tonsillitis. Methods A 106 children undergone tonsillectomy due to recurrent tonsillitis and a 127 healthy children aging between 2 and 12 years were enrolled in this study, to determine serum 25-hydroxyvitamin D level and vitamin D receptor gene polymorphisms (Apa1, Taq 1, fok1). Serum vitamin D level was measured with ELISA (nmol/L) and receptor gene polymorphism was determined by PCR. Vitamin D serum level below 80 nmol/L was accepted as insufficient. Results The average serum vitamin D level was 176 ± 79 nmol/L in recurrent tonsillitis group and 193 ± 56 nmol/L in control group. There was no significant difference between the groups ( p = 0.13). In recurrent tonsillitis group, 18% ( n = 15) of children had their serum vitamin D levels below 80 nmol/L. The vitamin D receptor gene polymorphism ( APA1 , TAQ 1 , FOK 1 ) in each group was compared ( AA , Aa , aa , TT , Tt , tt , FF , Ff , ff ). There was no significant difference between the two groups. The vitamin D serum levels and receptor sub-genotypes are also compared, and there was no significant difference between the groups. Conclusion There is no difference between the serum vitamin D level and receptor gene polymorphism among children with recurrent tonsillitis and healthy children. But vitamin D insufficiency is more prevalent in children with recurrent tonsillitis group (18%).
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2010.12.006