Submandibular salivary gland transfer for the prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma: 5-Year outcomes

Background Our aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation‐induced xerostomia in patients with nasopharyngeal carcinoma (NPC). Methods In all, there were 70 patients, consisting of a test group (36 patients) and a c...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2011-03, Vol.33 (3), p.389-395
Main Authors: Liu, Xue-Kui, Su, Yong, Jha, Naresh, Hong, Ming-Huan, Mai, Hai-Qiang, Fan, Wei, Zeng, Zong-Yuan, Guo, Zhu-Ming
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - radiotherapy
Neoplasm Staging
Otorhinolaryngology. Stomatology
Prospective Studies
Quality of Life
Radiation Injuries - complications
Radiation Injuries - prevention & control
radiation therapy
Reference Values
Risk Assessment
Salivary Glands - metabolism
Statistics, Nonparametric
Submandibular Gland - transplantation
submandibular glas transfer
Survival Analysis
Treatment Outcome
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Xerostomia - etiology
Xerostomia - prevention & control
xerostomia prevention
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Our aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation‐induced xerostomia in patients with nasopharyngeal carcinoma (NPC). Methods In all, there were 70 patients, consisting of a test group (36 patients) and a control group (34 patients) in a nonrandomized fashion. In the test group, the submandibular salivary gland was transferred to submental space before radiotherapy (XRT) and shielded. Salivary gland functions were evaluated by the amount of saliva and a quality of life questionnaire before and after XRT and 3 and 60 months after XRT. Results At 5 years, the trapping and excretion functions of salivary gland were significantly better in the test group (p = .000 and p = .000). The mean weight of saliva after XRT was heavier (1.65 g vs 0.73 g, p = .000), and the incidence of xerostomia was lower in the test group, with no difference in 5‐year survival and neck nodal recurrence between the 2 groups. Conclusions Salivary gland transfer procedure prevents XRT‐induced xerostomia and improves quality of life of patients with NPC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21461