Oral Epithelial Cells are Activated via TRP Channels

Transient receptor potential (TRP) ion channels are critical contributors to the perception of various environmental stimuli. Although the oral cavity is the access point for various food types, the expression of TRP channels in oral mucosa remains unknown. We hypothesized that the oral epithelium i...

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Bibliographic Details
Published in:Journal of dental research 2011-02, Vol.90 (2), p.163-167
Main Authors: Wang, B., Danjo, A., Kajiya, H., Okabe, K., Kido, M.A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - metabolism
Cells, Cultured
Dentistry
Epithelial Cells - metabolism
Epithelial Cells - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression
Male
Mouth Mucosa - cytology
Mouth Mucosa - metabolism
Mouth Mucosa - physiology
Rats
Rats, Sprague-Dawley
Sensation - physiology
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Transient Receptor Potential Channels - biosynthesis
Transient Receptor Potential Channels - genetics
Trigeminal Ganglion - metabolism
Vertebrates: nervous system and sense organs
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Summary:Transient receptor potential (TRP) ion channels are critical contributors to the perception of various environmental stimuli. Although the oral cavity is the access point for various food types, the expression of TRP channels in oral mucosa remains unknown. We hypothesized that the oral epithelium itself may participate in sensing thermal, mechanical, and chemical conditions. The expression profiles of TRP channels exhibited regional differences among the buccal, palatal, and tongue epithelia. Changes in elevated intracellular Ca2+ concentration ([Ca2+]i) in oral epithelial cells were found after stimulation of the TRP channels with capsaicin, camphor, 4α-phorbol-12,13 didecanoate (4α-PDD), 2-aminoethoxydiphenyl borate (2-APB), and menthol. These increases in Ca2+ appeared dependent on the TRP channels, because [Ca2+]i suppression was observed after the addition of the TRPV channel antagonist ruthenium red. These results demonstrate that the oral epithelia express various TRP channels and may have functional roles in sensory activities, together with neurons.
ISSN:0022-0345
1544-0591
DOI:10.1177/0022034510385459