Primary hepatic carcinosarcoma

BACKGROUND:Primary hepatic carcinosarcoma is a rare malignant tumor containing an intimate mixture of carci- nomatous and sarcomatous elements.Reports on risk factors, epidemiology,and pathogenesis of the tumor as well as the experience in its treatment are limited. METHOD:We present a case of prima...

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Published in:Hepatobiliary & pancreatic diseases international 2011-02, Vol.10 (1), p.101-103
Main Authors: Çelikbilek, Mehmet, Deniz, Kemal, Torun, Edip, Artis, Tarık, Özaslan, Ersin, Karahan, ökkeç İbrahim, Patiroğlu, Tahir Ercan, Özbakır, Ömer
Format: Article
Language:English
Subjects:
Aged
Biopsy
carcinosarcoma
Carcinosarcoma - diagnosis
Carcinosarcoma - pathology
Carcinosarcoma - surgery
cholangiocarcinoma
Cholangiocarcinoma - diagnosis
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Endocrinology & Metabolism
Frozen Sections
Gastroenterology and Hepatology
Humans
liver
liver neoplasms
Liver Neoplasms - diagnosis
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Magnetic Resonance Imaging
Male
neoplasms
osteosarcoma
Osteosarcoma - diagnosis
Osteosarcoma - pathology
Osteosarcoma - surgery
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Summary:BACKGROUND:Primary hepatic carcinosarcoma is a rare malignant tumor containing an intimate mixture of carci- nomatous and sarcomatous elements.Reports on risk factors, epidemiology,and pathogenesis of the tumor as well as the experience in its treatment are limited. METHOD:We present a case of primary carcinosarcoma of the liver in a 69-year-old man who complained of right hypochondrial pain and weight loss for two months. RESULTS:Magnetic resonance imaging revealed a 14×12 cm mass in segments 7-8 and 4 of the liver with vena hepatica invasion.An ultrasonography-guided biopsy showed osteoid tissue without osteoblastic rimming.Vascular structures accompanied the osteoid tissue.The patient underwent surgery after a diagnosis of hemangioma.Intraoperative frozen sections revealed a carcinosarcoma associated with an osteosarcoma and cholangiocellular carcinoma components. CONCLUSIONS:Preoperative diagnosis of this rare primary hepatic malignant tumor may be difficult by biopsy owing to intratumoral heterogeneity.Highly mature areas of the osteosarcomatous component may lead to misdiagnosis of metaplastic bone tissue.Clinicopathologic features of this rare entity are discussed.
ISSN:1499-3872
DOI:10.1016/S1499-3872(11)60015-5