Bioavailability of zinc from NutriSet zinc tablets compared with aqueous zinc sulfate

Background/Objectives: The apparent widespread extent of zinc (Zn) deficiency in developing countries and the efficacy of oral Zn supplements as an adjunct to oral rehydration therapy make oral Zn supplementation an increasingly important modality in clinical medicine and public health. In this stud...

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Bibliographic Details
Published in:European journal of clinical nutrition 2011-01, Vol.65 (1), p.125-131
Main Authors: Solomons, N.W, Romero-Abal, M.E, Weiss, G, Michalke, B, Schumann, K
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
aqueous solutions
Bioavailability
Biological and medical sciences
Biological Availability
brand name products
Developing Countries
dietary mineral supplements
Dietary Supplements
Dose-Response Relationship, Drug
drug formulations
Fasting
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Guatemala
human nutrition
Humans
Male
Medical sciences
men
Metabolic diseases
Middle Aged
nutrient availability
Pharmacology
Properties
tablets
Tablets - administration & dosage
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
Zinc
Zinc - administration & dosage
Zinc - blood
Zinc - pharmacokinetics
Zinc compounds
Zinc in the body
zinc sulfate
Zinc Sulfate - administration & dosage
Zinc Sulfate - pharmacokinetics
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Summary:Background/Objectives: The apparent widespread extent of zinc (Zn) deficiency in developing countries and the efficacy of oral Zn supplements as an adjunct to oral rehydration therapy make oral Zn supplementation an increasingly important modality in clinical medicine and public health. In this study we aimed to compare the relative bioavailability of oral doses of 30 mg of Zn in two dosing forms. Subjects/Methods: In total, 10 healthy male volunteers ingested oral Zn doses with 200 ml plain water at about 0830 hours in the fasting state on two occasions, once as 30 mg of Zn in an aqueous solution of reagent grade zinc sulfate (ZnSO4) and another time as 1.5 NutriSet Zn tablets (Nutriset, Malaunay, France); on a third occasion, only plain water was consumed. Venous blood specimens were collected at baseline, 60, 120, 180 and 240 min after ingestion and the plasma Zn was measured for each sample. Results: The relative bioavailability of oral Zn from a commonly used, tableted (NutriSet) form is only about half of that of a reference dose of aqueous ZnSO4 as indicated by the area under the curve of serial plasma Zn excursion and maximal change in circulating Zn. Conclusions: Reduced or absent functional outcomes in Zn intervention trials may derive, in part, from a lower than anticipated intestinal uptake of the Zn in the tableted form.
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2010.198