Nasal polyps: An independent risk factor for bronchial hyperresponsiveness in patients with allergic rhinitis

Many studies were conducted to figure out the relationship between allergic rhinitis (AR) and lower airway diseases. This study was designed to elucidate the clinical parameters that could predict the coexistence of bronchial hyperresponsiveness (BHR) in AR and suggest a guideline for lower airway e...

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Published in:American journal of rhinology & allergy 2010-09, Vol.24 (5), p.359-363
Main Authors: Ahn, Youngjin, An, Soo-Youn, Won, Tae-Bin, Kim, Jeong-Whun, Lee, Chul Hee, Min, Yang-Gi, Cho, Sang Heon, Park, Heung Woo, Koh, Young Yull, Kim, Sun Sin, Rhee, Chae-Seo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Bronchial Hyperreactivity - etiology
Child
Child, Preschool
Eosinophils - physiology
Female
Humans
Immunoglobulin E - blood
Logistic Models
Male
Middle Aged
Nasal Polyps - complications
Rhinitis, Allergic, Perennial - complications
Rhinitis, Allergic, Seasonal - complications
Risk Factors
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Summary:Many studies were conducted to figure out the relationship between allergic rhinitis (AR) and lower airway diseases. This study was designed to elucidate the clinical parameters that could predict the coexistence of bronchial hyperresponsiveness (BHR) in AR and suggest a guideline for lower airway evaluation in these patients. One hundred seventy-three patients newly diagnosed with AR were evaluated for the lower airway with the methacholine bronchoprovocation test. BHR was more prevalent in patients with nasal polyps (p = 0.01), in patients complaining of moderate to severe symptoms (p = 0.023), with higher serum total IgE levels (p = 0.001), and with blood eosinophil count (p = 0.008). No statistically significant difference was observed between intermittent and persistent AR patients (p = 0.364). Blood eosinophil count that could predict BHR was calculated as 320 cells/μL (p = 0.004). Instead of a routine lower airway evaluation for all AR patients, we recommend lower airway evaluation for the selected patients with nasal polyps, moderate to severe symptoms, and high blood eosinophil count.
ISSN:1945-8924
1945-8932
DOI:10.2500/ajra.2010.24.3502