Genetic Background and Expressivity of Histocompatibility Genes

A difference in the reactivity of F$_{1}$ hybrid female mice to skin grafts from male donors of each of their parental strains suggests that the genetic background can influence the efficacy of the Y antigen to elicit rejection of the graft.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1967-10, Vol.158 (3797), p.118-119
Main Authors: Silvers, Willys K., Billingham, R. E.
Format: Article
Language:English
Subjects:
Animals
Antigens
Female
Genes
Genetics
Genotype
Graft rejection
Histocompatibility
Hybridity
Hybridization, Genetic
Male
Male animals
Mice
Phenotype
Sex Chromosomes
Skin grafts
Skin Transplantation
Tissue grafting
Transplantation
Transplantation Immunology
Transplantation, Homologous
Y chromosome
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Description
Summary:A difference in the reactivity of F$_{1}$ hybrid female mice to skin grafts from male donors of each of their parental strains suggests that the genetic background can influence the efficacy of the Y antigen to elicit rejection of the graft.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.158.3797.118