Congenital heart block due to a lesion in the conduction system

The cardiac conduction system of an infant with congenital complete heart block was studied at postmortem examination by subserial sections of the interatrial and interventricular septa. A localized area of necrosis in the central fibrous body interrupted the penetrating portion of the bundle of His...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1970-04, Vol.45 (4), p.640-650
Main Authors: Sotelo-Avila, C, Rosenberg, H S, McNamara, D G
Format: Article
Language:English
Subjects:
Autopsy
Heart Block - congenital
Heart Block - etiology
Heart Conduction System - pathology
Heart Defects, Congenital - pathology
Humans
Infant, Newborn
Male
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Summary:The cardiac conduction system of an infant with congenital complete heart block was studied at postmortem examination by subserial sections of the interatrial and interventricular septa. A localized area of necrosis in the central fibrous body interrupted the penetrating portion of the bundle of His. The cardiac structure was intact, with no abnormality other than the lesions in the fibrous tissue. The lesion is interpreted as the result of an acquired inflammation late in intrauterine life, with damage localized to the cardiac central fibrous body.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.45.4.640