Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia

Summary Background TNF receptors (TNFR1 and TNFR2) and Fas belong to the system of apoptosis-signalling receptor molecules and may play a role in the pathogenesis of interstitial lung disease. Patients with cryptogenic organizing pneumonia (COP) usually respond well to corticosteroids, in contrast t...

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Bibliographic Details
Published in:Respiratory medicine 2011-02, Vol.105 (2), p.292-297
Main Authors: Ye, Qiao, Dai, Huaping, Sarria, Rafael, Guzman, Josune, Costabel, Ulrich
Format: Article
Language:English
Subjects:
Alveolar macrophage
Apoptosis
Biological and medical sciences
Bronchoalveolar Lavage
Cells, Cultured
Cryptogenic organizing pneumonia
Cryptogenic Organizing Pneumonia - genetics
Cryptogenic Organizing Pneumonia - metabolism
Cryptogenic Organizing Pneumonia - physiopathology
Cytokine
Cytokines
Disease
fas Receptor - metabolism
Female
Humans
Idiopathic Pulmonary Fibrosis - genetics
Idiopathic Pulmonary Fibrosis - metabolism
Idiopathic Pulmonary Fibrosis - physiopathology
Lung diseases
Lungs
Lymphocytes
Macrophages, Alveolar - metabolism
Male
Medical sciences
Middle Aged
Pathogenesis
Pneumology
Pneumonia
Proteins
Pulmonary/Respiratory
Receptors, Tumor Necrosis Factor, Type I - metabolism
Receptors, Tumor Necrosis Factor, Type II - metabolism
Respiratory system : syndromes and miscellaneous diseases
Sarcoidosis
Signal transduction
Tumor necrosis factor receptors
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Summary:Summary Background TNF receptors (TNFR1 and TNFR2) and Fas belong to the system of apoptosis-signalling receptor molecules and may play a role in the pathogenesis of interstitial lung disease. Patients with cryptogenic organizing pneumonia (COP) usually respond well to corticosteroids, in contrast to those with idiopathic pulmonary fibrosis (IPF). This may be due to the different pathogenesis. Methods The expression of TNFR1, TNFR2 and Fas on bronchoalveolar lavage (BAL) macrophages and lymphocytes was analysed in 9 patients with COP, 10 with IPF and 12 controls. The production of soluble TNFR1, 2 and TNF-α by alveolar macrophages was measured by ELISA. Results TNFR1 and Fas expression on alveolar macrophages was significantly higher in COP than in controls and IPF. The expression of TNFR2 on alveolar macrophages was also increased in COP compared to controls. The expression of TNFR2 and Fas on lymphocytes was significantly higher in COP than in IPF and controls. In addition, the expression of TNFR1, TNFR2 and Fas on BAL cells correlated positively with BAL lymphocytes ( p  
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2010.10.022