Effect of Methyldopa on Plasma Renin Activity in Man

The effect of methyldopa on plasma renin activity was studied in one hypertensive and four normotensive human volunteers. Peripheral venous blood for the estimation of plasma renin activity was obtained with the subjects supine and in a 70° head-up tilted position before, during and, in two subjects...

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Bibliographic Details
Published in:Circulation research 1969-11, Vol.25 (5), p.543-548
Main Authors: MOHAMMED, SHAKIL, FASOLA, ALFRED F, PRIVITERA, PHILIP J, LIPICKY, RAYMOND J, MARTZ, B L, GAFFNEY, THOMAS E
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - drug effects
Clinical Trials as Topic
Female
Humans
Male
Methyldopa - pharmacology
Middle Aged
Placebos
Posture
Renin - blood
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Summary:The effect of methyldopa on plasma renin activity was studied in one hypertensive and four normotensive human volunteers. Peripheral venous blood for the estimation of plasma renin activity was obtained with the subjects supine and in a 70° head-up tilted position before, during and, in two subjects, after treatment with oral methyldopa. Despite a reduction in mean arterial pressure, the plasma renin activity was decreased by methyldopa in each subject. The increase in plasma renin activity associated with tilting, however, was not significantly suppressed by methyldopa. These results indicate that treatment with methyldopa can simultaneously decrease mean arterial pressure and plasma renin activity and it is possible that these effects may be causally related.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.25.5.543