ANTIBIOTIC MSD-819. PREPARATION AND PROPERTIES OF BIOLOGICALLY ACTIVE DERIVATIVES

Seven derivatives of 6-chloro-2-quinoxalinecarboxylic acid 1, 4-dioxide were prepared. These include esters, amides and the acid hydrazide. The derivatives were tested against fifteen bacteria by agar diffusion assay and against two bacterial infections in vivo. Increased effectiveness on oral admin...

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Bibliographic Details
Published in:Journal of antibiotics 1969/07/25, Vol.22(7), pp.293-296
Main Authors: MILLER, THOMAS W., MILLER, A. KATHRINE, WOLF, FRANK J., STAPLEY, EDWARD O., HENDLIN, DAVID
Format: Article
Language:English
Subjects:
Acids
Alcaligenes - drug effects
Amides
Animals
Anti-Bacterial Agents - pharmacology
Bacillus - drug effects
Brucella - drug effects
Chemical Phenomena
Chemistry
Enterococcus faecalis - drug effects
Escherichia coli - drug effects
Esters
Mice
Proteus - drug effects
Pseudomonas aeruginosa - drug effects
Quinoxalines - pharmacology
Sarcina - drug effects
Serratia marcescens - drug effects
Staphylococcus - drug effects
Vibrio - drug effects
Xanthomonas - drug effects
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Summary:Seven derivatives of 6-chloro-2-quinoxalinecarboxylic acid 1, 4-dioxide were prepared. These include esters, amides and the acid hydrazide. The derivatives were tested against fifteen bacteria by agar diffusion assay and against two bacterial infections in vivo. Increased effectiveness on oral administration was observed with the carboxamide.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.22.293