In Vitro Effect of Knotolan, a New Lignan from Abies sibirica, on the Growth of Hormone-Dependent Breast Cancer Cells

Here we present antiestrogenic effects of Knotolan®, a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17β-estragiol on hormonedependent MCF-7 cells.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-10, Vol.149 (4), p.511-514
Main Authors: Zhukova, O. S, Fetisova, L. V, Trishin, A. V, Anisimova, N. Yu, Shcherbakov, A. E, Yashunskii, D. V, Tsvetkov, D. E, Men'shov, V. M, Kiselevskii, M. V, Nifant'ev, N. E
Format: Article
Language:eng ; rus
Subjects:
Abies - chemistry
Biomedical and Life Sciences
Biomedicine
Breast cancer
breast neoplasms
Breast Neoplasms - drug therapy
Butylene Glycols - therapeutic use
Cell Biology
Cell Line, Tumor
Cell Proliferation - drug effects
Estradiol - pharmacology
Estrogen
Female
Growth
Hormones
Humans
Internal Medicine
Isoflavones
Knotolan
Laboratory Medicine
lignans
Lignans - therapeutic use
Neoplasms, Hormone-Dependent - drug therapy
Pathology
plant estrogens
Postmenopausal women
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Description
Summary:Here we present antiestrogenic effects of Knotolan®, a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17β-estragiol on hormonedependent MCF-7 cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0981-5