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Treatment Adherence Therapy in People with Psychotic Disorders: Randomised Controlled Trial
Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To...
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Published in: | British journal of psychiatry 2010-12, Vol.197 (6), p.448-455 |
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container_title | British journal of psychiatry |
container_volume | 197 |
creator | Staring, A B P Van der Gaag, M Koopmans, G T Selten, J P Van Beveren, J M Hengeveld, M W Loonen, A J M Mulder, C L |
description | Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. Method: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). Results: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve. Conclusions: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission. Adapted from the source document. |
doi_str_mv | 10.1192/bjp.bp.109.077289 |
format | article |
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We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. Method: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). Results: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve. Conclusions: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission. Adapted from the source document.</description><identifier>ISSN: 0007-1250</identifier><identifier>DOI: 10.1192/bjp.bp.109.077289</identifier><identifier>CODEN: BJPYAJ</identifier><language>eng</language><subject>Adherence ; Admissions ; Interventions ; Involuntary ; Psychoses ; Quality of life</subject><ispartof>British journal of psychiatry, 2010-12, Vol.197 (6), p.448-455</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958,31035,33647,34566</link.rule.ids></links><search><creatorcontrib>Staring, A B P</creatorcontrib><creatorcontrib>Van der Gaag, M</creatorcontrib><creatorcontrib>Koopmans, G T</creatorcontrib><creatorcontrib>Selten, J P</creatorcontrib><creatorcontrib>Van Beveren, J M</creatorcontrib><creatorcontrib>Hengeveld, M W</creatorcontrib><creatorcontrib>Loonen, A J M</creatorcontrib><creatorcontrib>Mulder, C L</creatorcontrib><title>Treatment Adherence Therapy in People with Psychotic Disorders: Randomised Controlled Trial</title><title>British journal of psychiatry</title><description>Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. Method: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). Results: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve. Conclusions: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission. Adapted from the source document.</description><subject>Adherence</subject><subject>Admissions</subject><subject>Interventions</subject><subject>Involuntary</subject><subject>Psychoses</subject><subject>Quality of life</subject><issn>0007-1250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqNi7FOwzAURT2AREr5ALa3MTXYToIbtqoUdayqbAyVkzwUR45t_FxV_ftm4AM6nXOkexl7FTwXopbv7RjyNuSC1zlXSq7rB5ZxztVKyIo_sQXROGdRSpWxnyaiThO6BJt-wIiuQ2hm0eEKxsEBfbAIF5MGONC1G3wyHXwZ8rHHSJ9w1K73kyHsYetdit7aWZtotF2yx19tCV_--czevnfNdr8K0f-dkdJp_nVorXboz3RaF3Wl1Icsi_uXN9u5TGc</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Staring, A B P</creator><creator>Van der Gaag, M</creator><creator>Koopmans, G T</creator><creator>Selten, J P</creator><creator>Van Beveren, J M</creator><creator>Hengeveld, M W</creator><creator>Loonen, A J M</creator><creator>Mulder, C L</creator><scope>7QJ</scope></search><sort><creationdate>20101201</creationdate><title>Treatment Adherence Therapy in People with Psychotic Disorders: Randomised Controlled Trial</title><author>Staring, A B P ; Van der Gaag, M ; Koopmans, G T ; Selten, J P ; Van Beveren, J M ; Hengeveld, M W ; Loonen, A J M ; Mulder, C L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_8395776243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adherence</topic><topic>Admissions</topic><topic>Interventions</topic><topic>Involuntary</topic><topic>Psychoses</topic><topic>Quality of life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Staring, A B P</creatorcontrib><creatorcontrib>Van der Gaag, M</creatorcontrib><creatorcontrib>Koopmans, G T</creatorcontrib><creatorcontrib>Selten, J P</creatorcontrib><creatorcontrib>Van Beveren, J M</creatorcontrib><creatorcontrib>Hengeveld, M W</creatorcontrib><creatorcontrib>Loonen, A J M</creatorcontrib><creatorcontrib>Mulder, C L</creatorcontrib><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Staring, A B P</au><au>Van der Gaag, M</au><au>Koopmans, G T</au><au>Selten, J P</au><au>Van Beveren, J M</au><au>Hengeveld, M W</au><au>Loonen, A J M</au><au>Mulder, C L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment Adherence Therapy in People with Psychotic Disorders: Randomised Controlled Trial</atitle><jtitle>British journal of psychiatry</jtitle><date>2010-12-01</date><risdate>2010</risdate><volume>197</volume><issue>6</issue><spage>448</spage><epage>455</epage><pages>448-455</pages><issn>0007-1250</issn><coden>BJPYAJ</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>content type line 23</notes><notes>ObjectType-Feature-2</notes><abstract>Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. Method: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). Results: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve. Conclusions: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission. Adapted from the source document.</abstract><doi>10.1192/bjp.bp.109.077289</doi></addata></record> |
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source | Applied Social Sciences Index & Abstracts (ASSIA); Social Science Premium Collection; Sociology Collection; Cambridge University Press |
subjects | Adherence Admissions Interventions Involuntary Psychoses Quality of life |
title | Treatment Adherence Therapy in People with Psychotic Disorders: Randomised Controlled Trial |
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