Treatment Adherence Therapy in People with Psychotic Disorders: Randomised Controlled Trial

Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To...

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Bibliographic Details
Published in:British journal of psychiatry 2010-12, Vol.197 (6), p.448-455
Main Authors: Staring, A B P, Van der Gaag, M, Koopmans, G T, Selten, J P, Van Beveren, J M, Hengeveld, M W, Loonen, A J M, Mulder, C L
Format: Article
Language:English
Subjects:
Adherence
Admissions
Interventions
Involuntary
Psychoses
Quality of life
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Summary:Background: Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence. Aims: To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly. Method: Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159). Results: Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve. Conclusions: Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission. Adapted from the source document.
ISSN:0007-1250
DOI:10.1192/bjp.bp.109.077289