Effect of infectious bursal agent on the response of chickens to Newcastle disease and Marek's disease vaccination [Viral diseases]

White Leghorn chickens raised from one day old in an environment contaminated by the infectious bursal agent (IBA) had lower geometric mean titers (GMT) as measured by the hemagglutination-inhibition (HI) test to the Newcastle disease virus (NDV), than control Leghorns reared in an uncontaminated en...

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Bibliographic Details
Published in:Avian diseases 1976-07, Vol.20 (3), p.534-544
Main Authors: Giambrone, J. J., Eidson, C. S., Page, R. K., Fletcher, O. J., Barger, B. O., Kleven, S. H.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Bursa of Fabricius - immunology
Chickens
Chickens - immunology
Experimentation
Herpesviridae - immunology
Immunosuppression
Infections
Infectious bursal disease virus
Lesions
Marek Disease - immunology
Mortality
Newcastle disease
Newcastle Disease - immunology
Newcastle disease virus
Newcastle disease virus - immunology
Poultry Diseases - immunology
Reoviridae
Turkeys
Vaccination
Vaccination - veterinary
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Summary:White Leghorn chickens raised from one day old in an environment contaminated by the infectious bursal agent (IBA) had lower geometric mean titers (GMT) as measured by the hemagglutination-inhibition (HI) test to the Newcastle disease virus (NDV), than control Leghorns reared in an uncontaminated environment. Immunosuppression, defined as a reduction in GMT, was most pronounced at 35-56 days old for Leghorns vaccinated with NDV at 1 and 28 days or at 28 days. In a separate trial with broilers, immunosuppression was similar at 42-56 days old. This study also demonstrated that IBA infection in chickens increased susceptibility to Marek's disease (MD). The unvaccinated control chickens infected with IBA averaged 56.3% MD lesions, whereas unvaccinated controls not exposed to IBA averaged only 18.1% macroscopic lesions. It was also found that 20.7% of the HVT-vaccinated chickens exposed to IBA had gross MD lesions, whereas those HVT-vaccinated chickens reared in an environment free of IBA had 2.99% gross MD lesions.
ISSN:0005-2086
1938-4351
DOI:10.2307/1589386