AGGREGATION OF BLOOD PRESSURE IN INFANTS AND THEIR SIBLINGS

Sibling aggregation of blood pressure has been shown in children 2 to 14 years of age. To determine the earliest age at which this finding is detectable, blood pressures were evaluated in 98 siblings from 43 black families with newborns. Variances of blood pressure scores were significantly greater...

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Bibliographic Details
Published in:American journal of epidemiology 1976-05, Vol.103 (5), p.457-463
Main Authors: HENNEKENS, CHARLES H., JESSE, MARY JANE, KLEIN, BARBARA E., GOURLEY, JANET E., BLUMENTHAL, SIDNEY
Format: Article
Language:English
Subjects:
Adolescent
Blood Pressure
Child
Child, Preschool
Family
Female
Humans
Hypertension - genetics
Infant
Infant, Newborn
Male
newborn
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Summary:Sibling aggregation of blood pressure has been shown in children 2 to 14 years of age. To determine the earliest age at which this finding is detectable, blood pressures were evaluated in 98 siblings from 43 black families with newborns. Variances of blood pressure scores were significantly greater among families than within families for systolic (p < .025) but not diastolic pressures. Sib-sib intraclass correlation coefficients were .26 (95% two-sided confidence limits .05 to .47) for systolic and .16 (–.06 to .38) for diastolic pressures. When 1-month-old infant pressures were added, significant aggregation was present for systolic (p < .01) and diastolic (p < .025) pressures. The intraclass correlation coefficients were .21 (.02 to .38) and .17 (.03 to .34), respectively. When newborn scores were substituted, aggregation was not demonstrable. These data demonstrate a familial influence on blood pressure in infancy by 1 month of age.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a112247