Effect of uninephrectomy on glomerulotubular functional-structural balance in the dog

Effect of uninephrectomy on glomerulotubular functional-structural balance in the dog. Measurements of glomerular filtration (CIN), tubular glucose reabsorption (TmG) and nephron dimensions were made in dogs to determine if the compensatory adjustments in the surviving kidney following uninephrectom...

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Bibliographic Details
Published in:Kidney international 1974-02, Vol.5 (2), p.122-130
Main Authors: Bradley, Stanley E., Chien, Kuang-Chung H., Coelho, Jaime B., Mason, Richard C.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - analysis
Body Weight
Dogs
Female
Glomerular Filtration Rate
Glucose - metabolism
Glycosuria
Hypertrophy
Inulin
Kidney - physiopathology
Kidney Glomerulus - metabolism
Kidney Glomerulus - physiopathology
Kidney Tubules - metabolism
Kidney Tubules - physiopathology
Kidney Tubules, Proximal
Nephrectomy
Nephrons
Organ Size
Tritium
Urinary Diversion
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Summary:Effect of uninephrectomy on glomerulotubular functional-structural balance in the dog. Measurements of glomerular filtration (CIN), tubular glucose reabsorption (TmG) and nephron dimensions were made in dogs to determine if the compensatory adjustments in the surviving kidney following uninephrectomy affect individual nephrons and the nephron population uniformly. Both CIN and TmG increased proportionately within two to four days after nephrectomy in five dogs. Repeated measurement showed CIN and TmG levelling off after two weeks in two and after 56 days in the third, 30.9 to 82.8% and 28.5 to 72.9%, respectively, above control values. The relationship between filtered load and tubular reabsorption of glucose remained entirely normal throughout with no evidence of significant “splay”. A statistically significant correlation was obtained between glomerular surface area (GS) and the volume of the attached proximal convoluted tubule in random samples of nephrons isolated by microdissection from two control kidneys and from kidneys removed 4 days, 68 days, 156 days and four years after uninephrectomy. The volume of the proximal convolutions was significantly increased above control (renal weight-control, 24.9 g vs. hypertrophic, 29.5 g) without change in GS. It was concluded that the nephron population is uniformly affected while hemodynamic adjustments of glomerular filtration correct the glomerulotubular imbalance potentially inherent in the structural disproportionalities of compensatory hypertrophy. Effet de la néphrectomie unilatérale sur la balance glomérulotubulaire fonctionnelle et structurale chez le chien. Des mesures de la filtration glomérulaire (CIN), de la réabsorption tubulaire du glucose (TmG) et des mensurations des néphrons ont été faites chez des chiens afin de déterminer si les adjustements compensateurs du rein restant après néphrectomie unilatérale affectent uniformément les néphrons individuels et la population néphronique. CIN et TmG ont augmenté proportionnellement deuz à quatre jours après la néphrectomie chez cinq chiens. Des mesures itératives ont montré que CIN et TmG plafonnent après deux semaines chez deux chiens et 56 jours chez un troisième, à des valeurs supérieures aux contrôles de 30, 9 à 82,8% 28,5 à 72,9%, respectivement. La relation entre la charge filtrée et la réabsorption tubulaire du glucose demeure entièrement normale dans toute l'évolution, sans qu'apparaisse un évasement significatif de la courbe. Une corrélation s
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1974.16