Cadherins, steroids and cancer

The cadherins are a family of calcium-dependent cell adhesion molecules which are thought to be key regulators of morphogenesis. This review contains a discussion of the structure, function and regulation of these cell adhesion molecules. In particular, we discuss recent studies that demonstrate the...

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Bibliographic Details
Published in:Endocrine 1995-02, Vol.3 (2), p.83-89
Main Authors: Blaschuk, O W, Munro, S B, Farookhi, R
Format: Article
Language:English
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Summary:The cadherins are a family of calcium-dependent cell adhesion molecules which are thought to be key regulators of morphogenesis. This review contains a discussion of the structure, function and regulation of these cell adhesion molecules. In particular, we discuss recent studies that demonstrate the ability of steroids to modulate cadherin levelsin vivo. We speculate that steroids and estrogenic organochlorines exert their diverse morphoregulatory actions on tissues by altering cadherin levels.
ISSN:1355-008X
0969-711X
1559-0100
DOI:10.1007/BF02990057