Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder

Abstract Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an...

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Bibliographic Details
Published in:Journal of psychiatric research 2010-10, Vol.44 (13), p.847-852
Main Authors: Roepke, Stefan, Ziegenhorn, Andreas, Kronsbein, Julia, Merkl, Angela, Bahri, Scharif, Lange, Julia, Lübbert, Horst, Schweiger, Ulrich, Heuser, Isabella, Lammers, Claas-H
Format: Article
Language:English
Subjects:
17-alpha-Hydroxyprogesterone - blood
17α-Hydroxyprogesterone
Adult
Adult and adolescent clinical studies
Androgens
Androgens - blood
Androstenedione
Biological and medical sciences
Body Mass Index
Borderline personality disorder
Borderline Personality Disorder - blood
Borderline Personality Disorder - diagnosis
Borderline Personality Disorder - epidemiology
Borderline Personality Disorder - psychology
Case-Control Studies
Comorbidity
Depression
Depression - blood
Depression - psychology
Female
Female genital diseases
Glucose metabolism
Gynecology. Andrology. Obstetrics
Humans
Incidence
Indexing in process
Medical sciences
Metabolic diseases
Metabolism
Mood disorders
Non tumoral diseases
Obesity
PCO
Personality disorders
Polycystic ovaries
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - diagnosis
Polycystic Ovary Syndrome - epidemiology
Polycystic Ovary Syndrome - psychology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology
Psychopathology. Psychiatry
Risk Factors
Serum
Testosterone
Testosterone - blood
Visceral fat
Women
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Summary:Abstract Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2010.01.007